Disintegrin and metalloproteinase domain-containing protein 11 is anenzyme that in humans is encoded by theADAM11gene.[5][6]
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers".Nat Genet.5 (2):151–7.doi:10.1038/ng1093-151.PMID8252040.S2CID11770397.
Katagiri T, Harada Y, Emi M, Nakamura Y (1994). "Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing".Cytogenet. Cell Genet.68 (1–2):39–44.doi:10.1159/000133884.PMID7956356.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".Nat. Biotechnol.22 (6):707–16.doi:10.1038/nbt971.PMID15146197.S2CID27764390.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes".Genomics.84 (1):205–10.doi:10.1016/j.ygeno.2004.01.011.PMID15203218.
