Candidate List of substances of very high concern for Authorisation

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(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

Notes:

Authentic version:Only the Candidate List published on this website is deemed authentic. Companies may have immediate legal obligations following the inclusion of a substance in the Candidate List on this website including in particular Articles 7, 31 and 33 of the REACH Regulation.
Numerical identifiers: Each candidate list entry covers both anhydrous and hydrated forms of a substance. The CAS number shown in an entry is typically for the anhydrous form. Hydrated forms of the substance identified by other CAS numbers are still within the scope of the entry.
Other numerical identifiers: For those entries with "-" in the EC number and CAS number columns, a non-exhaustive inventory of EC and/or CAS Registry numbers describing substances or groups of substances considered to fall within the scope of the Candidate List entry is included, where practicably possible. This information can be accessed through the "Details" button of the selected entry.

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DecisionIUCLID dataset

1,1'-(ethane-1,2-diyl)bis[pentabromobenzene] (DBDPE)	284-366-9	84852-53-9	05-Nov-2025	vPvB (Article 57e)	D(2025)6375-DC	Details
tetra(sodium/potassium) 7-[(E)-{2-acetamido-4-[(E)-(4-{[4-chloro-6-({2-[(4-fluoro-6-{[4-(vinylsulfonyl)phenyl]amino}-1,3,5-triazine-2-yl)amino]propyl}amino)-1,3,5-triazine-2-yl]amino}-5-sulfonato-1-naphthyl)diazenyl]-5-methoxyphenyl}diazenyl]-1,3,6-naphthalenetrisulfonate (Reactive Brown 51) substance having a complex composition with <80% of the above constituents and other reaction side products	466-490-7	-	25-Jun-2025	Toxic for reproduction (Article 57c)	D(2025)4165-DC	Details
decamethyltetrasiloxane	205-491-7	141-62-8	25-Jun-2025	vPvB (Article 57e)	D(2025)4165-DC	Details
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane	241-867-7	17928-28-8	25-Jun-2025	vPvB (Article 57e)	D(2025)4165-DC	Details
reaction mass of: triphenylthiophosphate and tertiary butylated phenyl derivatives	421-820-9	192268-65-8	21-Jan-2025	PBT (Article 57d)	D(2024)7663-DC	Details
Perfluamine	206-420-2	338-83-0	21-Jan-2025	vPvB (Article 57e)	D(2024)7663-DC	Details
Octamethyltrisiloxane	203-497-4	107-51-7	21-Jan-2025	vPvB (Article 57e)	D(2024)7663-DC	Details
O,O,O-triphenyl phosphorothioate	209-909-9	597-82-0	21-Jan-2025	PBT (Article 57d)	D(2024)7663-DC	Details
6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid	701-118-1	2156592-54-8	21-Jan-2025	Toxic for reproduction (Article 57c)	D(2024)7663-DC	Details
Triphenyl phosphate	204-112-2	115-86-6	07-Nov-2024	Endocrine disrupting properties (Article 57(f) - environment)	D(2024)6225-DC	Details
Bis(α,α-dimethylbenzyl) peroxide	201-279-3	80-43-3	27-Jun-2024	Toxic for reproduction (Article 57c)	D(2024)4144-DC	Details
Oligomerisation and alkylation reaction products of 2-phenylpropene and phenol show/hide Phenol, methylstyrenated EC No.: 270-966-8 \| CAS No.: 68512-30-1	700-960-7	-	23-Jan-2024	vPvB (Article 57e)	D(2023)8585-DC	Details
Bumetrizole (UV-326)	223-445-4	3896-11-5	23-Jan-2024	vPvB (Article 57e)	D(2023)8585-DC	Details
2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one	438-340-0	119344-86-4	23-Jan-2024	Toxic for reproduction (Article 57c)	D(2023)8585-DC	Details
2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol (UV-329)	221-573-5	3147-75-9	23-Jan-2024	vPvB (Article 57e)	D(2023)8585-DC	Details
2,4,6-tri-tert-butylphenol	211-989-5	732-26-3	23-Jan-2024	Toxic for reproduction (Article 57c) PBT (Article 57d)	D(2023)8585-DC	Details
diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide	278-355-8	75980-60-8	14-Jun-2023	Toxic for reproduction (Article 57c)	D(2023)3788-DC	Details
bis(4-chlorophenyl) sulphone	201-247-9	80-07-9	14-Jun-2023	vPvB (Article 57e)	D(2023)3788-DC	Details
reaction mass of 2,2,3,3,5,5,6,6-octafluoro-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)morpholine and 2,2,3,3,5,5,6,6-octafluoro-4-(heptafluoropropyl)morpholine	473-390-7	-	17-Jan-2023	vPvB (Article 57e)	D(2022)9120-DC	Details
Perfluoroheptanoic acid and its salts show/hide potassium perfluoroheptanoate EC No.: - \| CAS No.: 21049-36-5 Perfluoroheptanoic acid EC No.: 206-798-9 \| CAS No.: 375-85-9 Sodium perfluoroheptanoate EC No.: 243-518-4 \| CAS No.: 20109-59-5 Ammonium perfluoroheptanoate EC No.: 228-098-2 \| CAS No.: 6130-43-4	-	-	17-Jan-2023	Toxic for reproduction (Article 57c) PBT (Article 57d) vPvB (Article 57e) Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2022)9120-DC	Details
Melamine	203-615-4	108-78-1	17-Jan-2023	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2022)9120-DC	Details
Isobutyl 4-hydroxybenzoate	224-208-8	4247-02-3	17-Jan-2023	Endocrine disrupting properties (Article 57(f) - human health)	D(2022)9120-DC	Details
bis(2-ethylhexyl) tetrabromophthalate covering any of the individual isomers and/or combinations thereof show/hide Bis(2-ethylhexyl) tetrabromophthalate EC No.: 247-426-5 \| CAS No.: 26040-51-7	-	-	17-Jan-2023	vPvB (Article 57e)	D(2022)9120-DC	Details
Barium diboron tetraoxide	237-222-4	13701-59-2	17-Jan-2023	Toxic for reproduction (Article 57c)	D(2022)9120-DC	Details
4,4'-sulphonyldiphenol	201-250-5	80-09-1	17-Jan-2023	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2022)9120-DC	Details
2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol	201-236-9	79-94-7	17-Jan-2023	Carcinogenic (Article 57a)	D(2022)9120-DC	Details
1,1'-[ethane-1,2-diylbisoxy]bis[2,4,6-tribromobenzene]	253-692-3	37853-59-1	17-Jan-2023	vPvB (Article 57e)	D(2022)9120-DC	Details
N-(hydroxymethyl)acrylamide	213-103-2	924-42-5	10-Jun-2022	Carcinogenic (Article 57a) Mutagenic (Article 57b)	D(2022)4187-DC	Details
tris(2-methoxyethoxy)vinylsilane	213-934-0	1067-53-4	17-Jan-2022	Toxic for reproduction (Article 57c)	D(2021)10043-DC	Details
S-(tricyclo(5.2.1.0'2,6)deca-3-en-8(or 9)-yl O-(isopropyl or isobutyl or 2-ethylhexyl) O-(isopropyl or isobutyl or 2-ethylhexyl) phosphorodithioate X4261	401-850-9	255881-94-8	17-Jan-2022	PBT (Article 57d)	D(2021)10043-DC	Details
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol	204-327-1	119-47-1	17-Jan-2022	Toxic for reproduction (Article 57c)	D(2021)10043-DC	Details
(±)-1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one covering any of the individual isomers and/or combinations thereof (4-MBC) show/hide (±)-1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one EC No.: 253-242-6 \| CAS No.: 36861-47-9 (3E)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 1782069-81-1 (1R,3E,4S)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 95342-41-9 (1S,3E,4R)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 852541-30-1 (1R,3Z,4S)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 852541-21-0(1R,4S)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 741687-98-9(1S,3Z,4R)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one EC No.: - \| CAS No.: 852541-25-4	-	-	17-Jan-2022	Endocrine disrupting properties (Article 57(f) - human health)	D(2021)10043-DC	Details
Phenol, alkylation products (mainly in para position) with C12-rich branched alkyl chains from oligomerisation, covering any individual isomers and/ or combinations thereof (PDDP) show/hide Phenol, dodecyl-, branched EC No.: 310-154-3 \| CAS No.: 121158-58-5 Phenol, (tetrapropenyl) derivatives EC No.: - \| CAS No.: 74499-35-7 Phenol, tetrapropylene- EC No.: - \| CAS No.: 57427-55-1 Phenol, 4-dodecyl, branched EC No.: - \| CAS No.: 210555-94-5 4-isododecylphenol EC No.: - \| CAS No.: 27459-10-5Phenol, 4-isododecyl- EC No.: - \| CAS No.: 27147-75-7	-	-	08-Jul-2021	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2021)4569-DC	Details
orthoboric acid, sodium salt show/hide Boric acid, sodium salt EC No.: 215-604-1 \| CAS No.: 1333-73-9 Trisodium orthoborate EC No.: 238-253-6 \| CAS No.: 14312-40-4 boric acid (H3BO3), sodium salt, hydrate EC No.: - \| CAS No.: 25747-83-5 boric acid (H3BO3), sodium salt (1:1) EC No.: - \| CAS No.: 14890-53-0 Boric acid (H3BO3), disodium salt EC No.: - \| CAS No.: 22454-04-2Orthoboric acid, sodium salt EC No.: 237-560-2 \| CAS No.: 13840-56-7	-	-	08-Jul-2021	Toxic for reproduction (Article 57c)	D(2021)4569-DC	Details
Medium-chain chlorinated paraffins (MCCP) UVCB substances consisting of more than or equal to 80% linear chloroalkanes with carbon chain lengths within the range from C14 to C17 show/hide Alkanes, C14-17, chloro EC No.: 287-477-0 \| CAS No.: 85535-85-9 Tetradecane, chloro derivs. EC No.: - \| CAS No.: 198840-65-2 Alkanes, C14-16, chloro EC No.: - \| CAS No.: 1372804-76-6 di-, tri- and tetrachlorotetradecane EC No.: - \| CAS No.: -	-	-	08-Jul-2021	PBT (Article 57d) vPvB (Article 57e)	D(2021)4569-DC	Details
glutaral	203-856-5	111-30-8	08-Jul-2021	Respiratory sensitising properties (Article 57(f) - human health)	D(2021)4569-DC	Details
4,4'-(1-methylpropylidene)bisphenol	201-025-1	77-40-7	08-Jul-2021	Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2021)4569-DC	Details
2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers show/hide 2-(4-tert-butylbenzyl)propionaldehyde EC No.: 201-289-8 \| CAS No.: 80-54-6 (2S)-3-(4-tert-butylphenyl)-2-methylpropanal EC No.: - \| CAS No.: 75166-30-2 (2R)-3-(4-tert-butylphenyl)-2-methylpropanal EC No.: - \| CAS No.: 75166-31-3	-	-	08-Jul-2021	Toxic for reproduction (Article 57c)	D(2021)4569-DC.pdf	Details
2,2-bis(bromomethyl)propane-1,3-diol (BMP); 2,2-dimethylpropan-1-ol, tribromo derivative/3-bromo-2,2-bis(bromomethyl)-1-propanol (TBNPA); 2,3-dibromo-1-propanol (2,3-DBPA) show/hide 2,2-dimethylpropan-1-ol, tribromo derivative (TBNPA) EC No.: 253-057-0 \| CAS No.: 36483-57-5 3-bromo-2,2-bis(bromomethyl)-1-propanol (TBNPA) EC No.: - \| CAS No.: 1522-92-5 2,2-bis(bromomethyl)propane-1,3-diol (BMP) EC No.: 221-967-7 \| CAS No.: 3296-90-0 2,3-dibromo-1-propanol (2,3-DBPA) EC No.: 202-480-9 \| CAS No.: 96-13-9	-	-	08-Jul-2021	Carcinogenic (Article 57a)	D(2021)4569-DC	Details
1,4-dioxane	204-661-8	123-91-1	08-Jul-2021	Carcinogenic (Article 57a) Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2021)4569-DC	Details
Dioctyltin dilaurate, stannane, dioctyl-, bis(coco acyloxy) derivs., and any other stannane, dioctyl-, bis(fatty acyloxy) derivs. wherein C12 is the predominant carbon number of the fatty acyloxy moiety show/hide dioctyltin dilaurate; stannane, dioctyl-, bis(coco acyloxy) derivs. EC No.: - \| CAS No.: - Stannane, dioctyl-, bis(coco acyloxy) derivs. EC No.: 293-901-5 \| CAS No.: 91648-39-4 Dioctyltin dilaurate EC No.: 222-883-3 \| CAS No.: 3648-18-8	-	-	19-Jan-2021	Toxic for reproduction (Article 57c)	D(2020)9139-DC	Details
Bis(2-(2-methoxyethoxy)ethyl)ether	205-594-7	143-24-8	19-Jan-2021	Toxic for reproduction (Article 57c)	D(2020)9139-DC	Details
Dibutylbis(pentane-2,4-dionato-O,O')tin	245-152-0	22673-19-4	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
Butyl 4-hydroxybenzoate	202-318-7	94-26-8	25-Jun-2020	Endocrine disrupting properties (Article 57(f) - human health)	D(2020)4578-DC	Details
2-methylimidazole	211-765-7	693-98-1	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
1-vinylimidazole	214-012-0	1072-63-5	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
Perfluorobutane sulfonic acid (PFBS) and its salts show/hide 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonic acid EC No.: 206-793-1 \| CAS No.: 375-73-5 Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate EC No.: 249-616-3 \| CAS No.: 29420-49-3 Ammonium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate EC No.: 269-513-7 \| CAS No.: 68259-10-9 magnesium perfluorobutanesulfonate EC No.: - \| CAS No.: 507453-86-3 lithium perfluorobutanesulfonate EC No.: - \| CAS No.: 131651-65-5N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate EC No.: - \| CAS No.: 25628-08-4bis(4-t-butylphenyl)iodonium perfluorobutanesulfonate EC No.: 432-660-4 \| CAS No.: 194999-85-4tetrabutyl-phosphonium nonafluoro-butane-1-sulfonate EC No.: 444-440-5 \| CAS No.: 220689-12-3dimethyl(phenyl)sulfanium perfluorobutanesulfonate EC No.: 452-310-4 \| CAS No.: 220133-51-71-(4-butoxy-1-naphthalenyl)tetrahydrothiophenium 1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonate EC No.: 468-770-4 \| CAS No.: -Triphenylsulfanium perfluorobutane sulfonate EC No.: 478-340-8 \| CAS No.: 144317-44-2morpholinium perfluorobutanesulfonate EC No.: - \| CAS No.: 503155-89-3	-	-	16-Jan-2020	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	ECHA_01_2020.pdf	Details
Diisohexyl phthalate	276-090-2	71850-09-4	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one ACETOCURE 97; GENOCURE*PMP; IGM 4817; IRGACURE 907; SPEEDCURE 97	400-600-6	71868-10-5	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone CG 25-369; IRGACURE 369; TK 11-319	404-360-3	119313-12-1	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details

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Candidate List of substances of very high concern for Authorisation

Candidate List of substances of very high concern for Authorisation

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(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

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