Abstract
The etiopathology of Alzheimer’s disease (AD) is extremely complex and heterogeneous, often associated withcomorbidities. As a result it may be unlikely that AD may be mitigated by drug acting on a single specific target. The currenttendency in drug design and discovery in AD is the rational design or “serendipitous” discovery of new drug entitieschallenging multiple targets. Since two of the presently approved drugs for AD are based on natural products (galantamineand the physostigmine-derivative rivastigmine), many plants are now under investigation as a potential source of newdrugs. Multifunctional drugs often have their origin in natural sources. This review is limited to plant chemicals havingdifferent targets with actual (galantamine) or promising (drugs from Crocus sativus, Ginkgo biloba, Salvia species, andHuperzia serrata) clinical evidence in people with dementia or AD.
Keywords:Alzheimer’s disease, cholinergic system, crocus sativus, drug discovery and development, galantamine, ginkgobiloba, huperzia serrata, multitargets, nicotine, nAChR, plant drug, salvia species, systems biology
Current Medicinal Chemistry
Title:Multitarget Drugs of Plants Origin Acting on Alzheimer's Disease
Volume: 20Issue: 13
Author(s):P. Russo, A. Frustaci, A. Del Bufalo, M. Fini and A. Cesario
Affiliation:
Keywords:Alzheimer’s disease, cholinergic system, crocus sativus, drug discovery and development, galantamine, ginkgobiloba, huperzia serrata, multitargets, nicotine, nAChR, plant drug, salvia species, systems biology
Abstract: The etiopathology of Alzheimer’s disease (AD) is extremely complex and heterogeneous, often associated withcomorbidities. As a result it may be unlikely that AD may be mitigated by drug acting on a single specific target. The currenttendency in drug design and discovery in AD is the rational design or “serendipitous” discovery of new drug entitieschallenging multiple targets. Since two of the presently approved drugs for AD are based on natural products (galantamineand the physostigmine-derivative rivastigmine), many plants are now under investigation as a potential source of newdrugs. Multifunctional drugs often have their origin in natural sources. This review is limited to plant chemicals havingdifferent targets with actual (galantamine) or promising (drugs from Crocus sativus, Ginkgo biloba, Salvia species, andHuperzia serrata) clinical evidence in people with dementia or AD.
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Russo P., Frustaci A., Del Bufalo A., Fini M. and Cesario A., Multitarget Drugs of Plants Origin Acting on Alzheimer's Disease, Current Medicinal Chemistry 2013; 20 (13) .https://dx.doi.org/10.2174/0929867311320130008
| DOI https://dx.doi.org/10.2174/0929867311320130008 | Print ISSN 0929-8673 |
| Publisher Name Bentham Science Publisher | Online ISSN 1875-533X |
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