Abstract
There is a causal relationship between cancer (including colorectal cancer),chronic systemic inflammation and persistent infections, and the presence of dysregulatedcirculating inflammatory markers. It is known that aberrant clot formation and coagulopathiesoccur in systemic inflammation. In colorectal cancer, there is a close link betweengut dysbiosis and an inflammatory profile. In this review, we present evidence ofthe connection between gut dysbiosis, the entry of bacteria into the internal environment,and the presence of their highly potent inflammagenic molecules, such aslipopolysaccharide and lipoteichoic acid, in circulation. These bacterial components mayact as one of the main drivers of the inflammatory process (including hypercoagulation)in colorectal cancer. We review literature that points to the role of these bacterial inflammagensand how they contribute to colorectal carcinogenesis. Insight into the factors thatpromote carcinogenesis is crucial to effectively prevent and screen for colorectal cancer.Early diagnosis of an activated coagulation system and the detection of bacterial componentsin circulation and also in the tumour microenvironment, could therefore be important,and may also, together with modulation of the gut microbiota, serve as potential therapeutictargets.
Keywords:Colorectal cancer, gut microbiome, bacterial inflammagens, inflammation, hypercoagulation, tumour development.
Current Medicinal Chemistry
Title:The Link Between Bacterial Inflammagens, Leaky Gut Syndrome andColorectal Cancer
Volume: 28Issue: 41
Author(s):Greta M de Waal*, Willem J.S. de Villiers and Etheresia Pretorius*
Affiliation:
- Department of Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1 Matieland,7602, South Africa
- Department of Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1 Matieland,7602, South Africa
Keywords:Colorectal cancer, gut microbiome, bacterial inflammagens, inflammation, hypercoagulation, tumour development.
Abstract: There is a causal relationship between cancer (including colorectal cancer),chronic systemic inflammation and persistent infections, and the presence of dysregulatedcirculating inflammatory markers. It is known that aberrant clot formation and coagulopathiesoccur in systemic inflammation. In colorectal cancer, there is a close link betweengut dysbiosis and an inflammatory profile. In this review, we present evidence ofthe connection between gut dysbiosis, the entry of bacteria into the internal environment,and the presence of their highly potent inflammagenic molecules, such aslipopolysaccharide and lipoteichoic acid, in circulation. These bacterial components mayact as one of the main drivers of the inflammatory process (including hypercoagulation)in colorectal cancer. We review literature that points to the role of these bacterial inflammagensand how they contribute to colorectal carcinogenesis. Insight into the factors thatpromote carcinogenesis is crucial to effectively prevent and screen for colorectal cancer.Early diagnosis of an activated coagulation system and the detection of bacterial componentsin circulation and also in the tumour microenvironment, could therefore be important,and may also, together with modulation of the gut microbiota, serve as potential therapeutictargets.
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Cite this article as:
de Waal M Greta *, de Villiers J.S. Willem and Pretorius Etheresia*, The Link Between Bacterial Inflammagens, Leaky Gut Syndrome andColorectal Cancer, Current Medicinal Chemistry 2021; 28 (41) .https://dx.doi.org/10.2174/0929867328666210219142737
| DOI https://dx.doi.org/10.2174/0929867328666210219142737 | Print ISSN 0929-8673 |
| Publisher Name Bentham Science Publisher | Online ISSN 1875-533X |
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