1. Kim RH, Armstrong AW. Current state of acne treatment: highlighting lasers, photodynamic therapy, and chemical peels. Dermatol Online J 2011 Mar; 17(3): 2

   PubMed  Google Scholar 

2. Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet 2012 Jan 28; 379(9813): 361–72

   Article PubMed  Google Scholar 

3. Ghodsi SZ, Orawa H, Zouboulis CC. Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol 2009 Sep; 129(9): 2136–41

   Article PubMed CAS  Google Scholar 

4. Dréno Recent data on epidemiology of acne [in French]. Ann Dermatol Venereol 2010 Nov; 137 Suppl. 2: S49–51

   Google Scholar 

5. Goçalves G, Amado J, Matos M, et al. The prevalence of acne among a group of Portuguese medical students. J Eur Acad Dermatol Venereol 2012 Apr; 26(4): 514–7

   Article  Google Scholar 

6. Perkins AC, Maglione J, Hillebrand GG, et al. Acne vulgaris in women: prevalence across the life span. J Womens Health (Larchmt) 2012 Feb; 21(2): 223–30

   Article  Google Scholar 

7. Golchai J, Khani SH, Heidarzadeh A, et al. Comparison of anxiety and depression in patients with acne vulgaris and healthy individuals. Indian J Dermatol 2010 Oct; 55(4): 352–4

   Article PubMed  Google Scholar 

8. Dunn LK, O’Neill JL, Feldman SR. Acne in adolescents: quality of life, self-esteem, mood, and psychological disorders. Dermatol Online J 2011 Jan 15; 17(1):1

   PubMed  Google Scholar 

9. Gollnick H, Cunliffe W, Berson D, et al., Global Alliance to Improve Outcomes in Acne. Management of acne: a report from a Global Alliance to Improve Out-comes in Acne. J Am Acad Dermatol 2003 Jul; 49 (1 Suppl.): S1–37

   Article PubMed  Google Scholar 

10. Strauss JS, Krowchuk DP, Leyden JJ, et al. Guidelines of care for acne vulgaris management. J Am Acad Dermatol 2007 Apr; 56(4): 651–63

    Article PubMed  Google Scholar 

11. Dréno Bettoli V, Ochsendorf F, et al. European recommendations on the use of oral antibiotics for acne. Eur J Dermatol 2004 Nov–Dec; 14 (6): 391–9

    Google Scholar 

12. Nast A, Bayerl C, Borelli C, et al. S2k-guideline for therapy of acne [in German]. J Dtsch Dermatol Ges 2010 Jul; 8 Suppl. 2: s1–59

    PubMed  Google Scholar 

13. Thielitz A, Gollnick H. Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol 2008; 9(6): 369–81

    Article PubMed  Google Scholar 

14. Yentzer BA, McClain RW, Feldman SR. Do topical retinoids cause acne to“flare”? J Drugs Dermatol 2009 Sep; 8_(9): 799–801

    Google Scholar 

15. Gollnick HP, Finlay AY, Shear N. Can we define acne as a chronic disease? If so, how and when? Am J Clin Dermatol 2008; 9_(5): 279–84

    Article  Google Scholar 

16. Cunliffe WJ, Poncet M, Loesche C, et al. A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials. Br J Dermatol 1998 Oct; 139 Suppl. 52: 48–56

    Article PubMed CAS  Google Scholar 

17. Eichenfield LF, Wortzman M. A novel gel formulation of 0.25% tretinoin and 1.2% clindamycin phosphate: efficacy in acne vulgaris patients aged 12 to 18 years. Pediatr Dermatol 2009 May–Jun; 26(3): 257–61

    Article PubMed  Google Scholar 

18. Webster GF. Evidence-based review: fixed-combination therapy and topical retinoids in the treatment of acne. J Drugs Dermatol 2011 Jun; 10(6): 636–44

    PubMed  Google Scholar 

19. Eichenfield LF, Alió Sáenz AB. Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study. J Drugs Dermatol 2011 Dec 1; 10(12): 1382–96

    PubMed CAS  Google Scholar 

20. Gold LS, Tan J, Cruz-Santana A, et al. A North American study of adapalene- benzoyl peroxide combination gel in the treatment of acne. Cutis 2009 Aug; 84(2): 110–6

    PubMed  Google Scholar 

21. Lucky AW, Sugarman J. Comparison of micronized tretinoin gel 0.05% and tretinoin gel microsphere 0.1% in young adolescents with acne: a post hoc analysis of efficacy and tolerability data. Cutis 2011 Jun; 87(6): 305–10

    PubMed  Google Scholar 

22. Torok HM, Pillai R. Safety and efficacy of micronized tretinoin gel (0.05%) in treating adolescent acne. J Drugs Dermatol 2011 Jun; 10(6): 647–52

    PubMed  Google Scholar 

23. Castro GA, Oliveira CA, Mahecha GA, et al. Comedolytic effect and reduced skin irritation of a new formulation of all-trans retinoic acid-loaded solid lipid nanoparticles for topical treatment of acne. Arch Dermatol Res 2011 Sep; 303(7): 513–20

    Article PubMed CAS  Google Scholar 

24. Lee HE, Ko JY, Kim YH, et al. A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris. Eur J Dermatol 2011 Nov–Dec; 21(6): 959–65

    PubMed CAS  Google Scholar 

25. Ganceviciene R, Zouboulis CC. Isotretinoin: state of the art treatment for acne vulgaris. J Dtsch Dermatol Ges 2010 Mar; 8 Suppl. 1: S47–59

    PubMed  Google Scholar 

26. Rigopoulos D, Larios G, Katsambas AD. The role of isotretinoin in acne therapy: why not as first-line therapy? Facts and controversies. Clin Dermatol 2010 Jan–Feb; 28(1): 24–30

    Article PubMed  Google Scholar 

27. Agarwal US, Besarwal RK, Bhola K. Oral isotretinoin in different dose regimens for acne vulgaris: a randomized comparative trial. Indian J Dermatol Venereol Leprol 2011 Nov-Dec; 77(6): 688–94

    Article PubMed  Google Scholar 

28. Lee JW, Yoo KH, Park KY, et al. Effectiveness of conventional, low-dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study. Br J Dermatol 2011 Jun; 164(6): 1369–75

    Article PubMed CAS  Google Scholar 

29. Bernstein CN, Nugent Z, Longobardi T, et al. Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study. Am J Gastroenterol 2009 Nov; 104(11): 2774–8

    Article PubMed CAS  Google Scholar 

30. Crockett SD, Porter CQ, Martin CF, et al. Isotretinoin use and the risk of inflammatory bowel disease: a case-control study. Am J Gastroenterol 2010 Sep; 105(9): 1986–93

    Article PubMed  Google Scholar 

31. Marqueling AL, Zane LT. Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review. Semin Cutan Med Surg 2007 Dec; 26(4): 210–20

    Article PubMed CAS  Google Scholar 

32. Halvorsen JA, Stern RS, Dalgard F, et al. Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study. J Invest Dermatol 2011 Feb; 131(2): 363–70

    Article PubMed CAS  Google Scholar 

33. Langan SM, Batchelor JM. Acne, isotretinoin and suicide attempts: a critical appraisal. Br J Dermatol 2011 Jun; 164(6): 1183–5

    Article PubMed CAS  Google Scholar 

34. Sundström A, Alfredsson L, Sjölin-Forsberg G, et al. Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study. BMJ 2010 Nov 11; 341: c5812

    Article PubMed  Google Scholar 

35. Lowenstein EB, Lowenstein EJ. Isotretinoin systemic therapy and the shadow cast upon dermatology’s downtrodden hero. Clin Dermatol 2011 Nov–Dec; 29(6): 652–61

    Article  Google Scholar 

36. Ross JI, Snelling AM, Carnegie E, et al. Antibiotic-resistant acne: lessons from Europe. Br J Dermatol 2003 Mar; 148(3): 467–78

    Article PubMed CAS  Google Scholar 

37. Simonart T, Dramaix M. Treatment of acne with topical antibiotics: lessons from clinical studies. Br J Dermatol 2005 Aug; 153(2): 395–403

    Article PubMed CAS  Google Scholar 

38. Thiboutot D, Gollnick H, Bettoli V, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol 2009 May; 60 (5 Suppl.): S1–50

    Article PubMed  Google Scholar 

39. Ozolins M, Eady EA, Avery AJ, et al. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial. Lancet 2004 Dec 18–31; 364(9452): 2188–95

    Article PubMed CAS  Google Scholar 

40. Simonart T, Dramaix M, De Maertelaer V. Efficacy of tetracyclines in the treatment of acne vulgaris: a review. Br J Dermatol 2008 Feb; 158(2): 208–16

    PubMed CAS  Google Scholar 

41. Ochsendorf F. Minocycline in acne vulgaris: benefits and risks. Am J Clin Dermatol 2010; 11(5): 327–41

    Article PubMed  Google Scholar 

42. Skidmore R, Kovach R, Walker C, et al. Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne. Arch Dermatol 2003 Apr; 139(4): 459–64

    Article PubMed CAS  Google Scholar 

43. Toossi P, Farshchian M, Malekzad F, et al. Subantimicrobial-dose doxycycline in the treatment of moderate facial acne. J Drugs Dermatol 2008 Dec; 7(12): 1149–52

    PubMed  Google Scholar 

44. Brandstetter AJ, Maibach HI. Topical dose justification: benzoyl peroxide concentrations. J Dermatolog Treat. Epub 2011 Dec 27

45. Hughes BR, Norris JF, Cunliffe WJ. A double-blind evaluation of topical isotretinoin 0.05%, benzoyl peroxide gel 5% and placebo in patients with acne. Clin Exp Dermatol 1992 May; 17(3): 165–8

    Article PubMed CAS  Google Scholar 

46. Harper JC. Benzoyl peroxide development, pharmacology, formulation and clinical uses in topical fixed-combinations. J Drugs Dermatol 2010 May; 9(5): 482–7

    PubMed  Google Scholar 

47. Choudhury S, Chatterjee S, Sarkar DK, et al. Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: a randomized controlled trial. Indian J Pharmacol 2011 Nov; 43(6): 628–31

    PubMed CAS  Google Scholar 

48. Seidler EM, Kimball AB. Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne. J Am Acad Dermatol 2010 Jul; 63(1): 52–62

    Article PubMed CAS  Google Scholar 

49. Gollnick HP, Graupe Zaumseil RP. Azelaic acid 15% gel in the treatment of acne vulgaris: combined results of two double-blind clinical comparative studies [in German]. J Dtsch Dermatol Ges 2004 Oct; 2(10): 841–7

    Article PubMed  Google Scholar 

50. Stinco G, Bragadin G, Trotter D, et al. Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. J Eur Acad Dermatol Venereol 2007 Mar; 21(3): 320–5

    Article PubMed CAS  Google Scholar 

51. Katsambas A, Graupe Stratigos J. Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris: comparison with vehicle and topical tretinoin. Acta Derm Venereol Suppl (Stockh) 1989; 143: 35–9

    CAS  Google Scholar 

52. Stotland M, Shalita AR, Kissling RF. Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. Am J Clin Dermatol 2009; 10(4): 221–7

    Article PubMed  Google Scholar 

53. Pickert A, Raimer S. An evaluation of dapsone gel 5% in the treatment of acne vulgaris. Expert Opin Pharmacother 2009 Jun; 10(9): 1515–21

    Article PubMed CAS  Google Scholar 

54. Kircik LH. Harnessing the anti-inflammatory effects of topical dapsone for management of acne. J Drugs Dermatol 2010 Jun; 9(6): 667–71

    PubMed  Google Scholar 

55. Marcinkiewicz J, Wojas-Pelc A, Walczewska M, et al. Topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study. Eur J Dermatol 2008 Jul–Aug; 18(4): 433–9

    PubMed CAS  Google Scholar 

56. Dréno Fischer TC, Perosino E, et al. Expert opinion: efficacy of superficial chemical peels in active acne management: what can we learn from the literature today? Evidence-based recommendations. J Eur Acad Dermatol Venereol 2011 Jun; 25(6): 695–704

    Article  Google Scholar 

57. Takenaka Y, Hayashi N, Takeda M, et al. Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. J Dermatol 2012 Apr; 39(4): 350–4

    Article PubMed CAS  Google Scholar 

58. Akarsu S, Fetil E, Yücel F, et al. Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris. J Dermatol 2012 May; 39(5): 433–8

    Article PubMed CAS  Google Scholar 

59. Del Rosso JQ. The use of sodium sulfacetamide 10%-sulfur 5% emollient foam in the treatment of acne vulgaris. J Clin Aesthet Dermatol 2009 Aug; 2(8): 26–9

    Google Scholar 

60. Fabbrocini G, Staibano S, De Rosa G, et al. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. Am J Clin Dermatol 2011 Apr 1; 12(2): 133–41

    Article PubMed  Google Scholar 

61. Arowojolu Gallo MF, Lopez LM, et al. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev 2009 Jul; 8(3): CD004425

    Google Scholar 

62. Guerra-Tapia A, Sancho Pérez Ethinylestradiol/chlormadinone acetate: dermatological benefits. Am J Clin Dermatol 2011 Sep 6; 12 Suppl. 1:3–11

    Article PubMed  Google Scholar 

63. Frangos JE, Alavian CN, Kimball AB. Acne and oral contraceptives: update on women’s health screening guidelines. J Am Acad Dermatol 2008 May; 58(5): 781–6

    Article PubMed  Google Scholar 

64. Brown J, Farquhar C, Lee O, et al. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2009 Apr 15; (2): CD000194

    PubMed  Google Scholar 

65. Gribbon EM, Shoesmith JG, Cunliffe WJ, et al. The microaerophily and photosensitivity of Propionibacterium acnes. J Appl Bacteriol 1994 Nov; 77(5): 583–90

    Article PubMed CAS  Google Scholar 

66. Ross EV. Optical treatments for acne. Dermatol Ther 2005 May–Jun; 18 (3): 253–66

    Article PubMed  Google Scholar 

67. Papageorgiou P, Katsambas A, Chu A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol 2000 May; 142(5): 973–8

    Article PubMed CAS  Google Scholar 

68. Tzung TY, Wu KH, Huang ML. Blue light phototherapy in the treatment of acne. Photodermatol Photoimmunol Photomed 2004 Oct; 20(5): 266–9

    Article PubMed  Google Scholar 

69. Haedersdal M, Togsverd-Bo K, Wulf HC. Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris. J Eur Acad Dermatol Venereol 2008 Mar; 22(3): 267–78

    Article PubMed CAS  Google Scholar 

70. Hamilton FL, Car J, Lyons C, et al. Laser and other light therapies for the treatment of acne vulgaris: systematic review. Br J Dermatol 2009 Jun; 160(6): 1273–85

    Article PubMed CAS  Google Scholar 

71. Jih MH, Kimyai-Asadi A. Laser treatment of acne vulgaris. Semin Plast Surg 2007 Aug; 21(3): 167–74

    Article PubMed  Google Scholar 

72. Gold MH, Biron J. Efficacy of a novel combination of pneumatic energy and broadband light for the treatment of acne. J Drugs Dermatol 2008 Jul; 7(7): 639–42

    PubMed  Google Scholar 

73. Shamban AT, Enokibori M, Narurkar V, et al. Photopneumatic technology for the treatment of acne vulgaris. J Drugs Dermatol 2008 Feb; 7(2): 139–45

    PubMed  Google Scholar 

74. Reuter J, Merfort I, Schempp CM. Botanicals in dermatology: an evidence-based review. Am J Clin Dermatol 2010; 11(4): 247–67

    PubMed  Google Scholar 

75. Simonart T, Kabagabo De Maertelaer V. Homoeopathic remedies in dermatology: a systematic review of controlled clinical trials. Br J Dermatol 2011 Oct; 165(4): 897–905

    Article PubMed CAS  Google Scholar 

76. Magin PJ, Adams J, Pond CD, et al. Topical and oral CAM in acne: a review of the empirical evidence and a consideration of its context. Complement Ther Med 2006 Mar; 14(1): 62–76

    Article PubMed CAS  Google Scholar 

77. Simpson RC, Grindlay DJ, Williams HC. What’s new in acne? An analysis of systematic reviews and clinically significant trials published in 2010–11. Clin Exp Dermatol 2011 Dec; 36(8): 840–3

    Article PubMed CAS  Google Scholar 

78. Koku Aksu AE, Metintas S, Saracoglu ZN, et al. Acne: prevalence and relationship with dietary habits in Eskisehir, Turkey. J Eur Acad Dermatol Venereol. Epub 2011 Nov 10

79. Veith WB, Silverberg NB. The association of acne vulgaris with diet. Cutis 2011 Aug; 88(2): 84–91

    PubMed  Google Scholar 

80. Cordain L, Lindeberg S, Hurtado M, et al. Acne vulgaris: a disease of Western civilization. Arch Dermatol 2002 Dec; 138(12): 1584–90

    Article PubMed  Google Scholar 

81. Smith RN, Mann NJ, Braue A, et al. The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial. J Am Acad Dermatol 2007 Aug; 57(2): 247–56

    Article PubMed  Google Scholar 

82. Danby FW. Nutrition and acne. Clin Dermatol 2010 Nov–Dec; 28(6): 598–604

    Article  Google Scholar 

83. Kim J. Acne vaccines: therapeutic option for the treatment of acne vulgaris? J Invest Dermatol 2008 Oct; 128(10): 2353–4

    Article PubMed CAS  Google Scholar 

84. Rubinchik E, Dugourd D, Algara T, et al. Antimicrobial and antifungal activities of a novel cationic antimicrobial peptide, omiganan, in experimental skin colonisation models. Int J Antimicrob Agents 2009 Nov; 34(5): 457–61

    Article PubMed CAS  Google Scholar 

85. Wang Y, Zhang Z, Chen L, et al. Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris. PLoS ONE 2011; 6(7): e22120

    Article PubMed CAS  Google Scholar 

86. Nakatsuji T, Kao MC, Fang JY, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol 2009 Oct; 129(10): 2480–8

    Article PubMed CAS  Google Scholar 

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