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Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases

An Evidence-Based Update to Important Clinical Questions

  • Review Article
  • Non-Infectious Granulomatous Diseases of the Skin
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American Journal of Clinical Dermatology Aims and scope Submit manuscript

Abstract

Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with systemic diseases that impact the patient’s overall prognosis. In this update, we offer a discussion of emerging concepts and controversies in this field, as presented through evidence-based answers to seven important clinical questions regarding palisading and epithelioid granulomata. These questions offer an opportunity to review ten non-infectious granulomatous conditions that have implications for systemic disease: granuloma annulare, annular elastolytic giant cell granuloma, necrobiosis lipoidica, methotrexate-induced accelerated rheumatoid nodulosis, necrobiotic xanthogranuloma, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, palisaded neutrophilic granulomatous dermatitis, sarcoidosis, and metastatic Crohn disease. Recent clinical, epidemiologic, and laboratory studies have shed some light on these diseases, the association of these conditions with systemic disorders, and their overall prognoses.

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No sources of funding were used to assist in the preparation of this review. The authors have no conflicts of interest that are directly relevant to the content of this review.

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  1. Department of Dermatology, University of Pittsburgh, School of Medicine University of Pittsburgh Medical Center, 200 Lothrop St., Presby South Tower, Suite 3825, Pittsburgh, Pennsylvania, 15213, USA

    Elena Balestreire Hawryluk, Leonid Izikson & Joseph C. English III MD (Assoc. Prof. of Dermatology, Clinical Vice-Chairman for Quality and Innovation)

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  1. Elena Balestreire Hawryluk

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  2. Leonid Izikson

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  3. Joseph C. English III MD

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Correspondence toJoseph C. English III MD.

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Hawryluk, E.B., Izikson, L. & English, J.C. Non-Infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases.Am J Clin Dermatol11, 171–181 (2010). https://doi.org/10.2165/11530080-000000000-00000

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