Novel application of three-dimensional HDlive imaging in prenatal diagnosis from the first trimester
- Ritsuko Kimata Pooh
andAsim Kurjak
Abstract
Recent development of three-dimensional (3D) high definition (HD) ultrasound has resulted in remarkable progress in visualization of early embryos and fetuses in sonoembryology. The new technology of HDlive assesses both structural and functional developments in the first trimester with greater reliably than two-dimensional (2D) ultrasound. The ability to visualize not only fetal face, hands, fingers, feet, and toes, but also amniotic membranes, is better with volumetric ultrasound than 2D ultrasound. In this article, detailed and comprehensive structures of normal and abnormal fetuses depicted by 3D HDlive are presented, including various faces of Down’s syndrome and holoprosencephaly, as well as low-set ear and finger/toe abnormalities from the first trimester. Three-dimensional HDlive further “humanizes” the fetus, enables detailed observation of the fetal face in the first trimester as shown in this article, and reveals that a small fetus is not more a fetus but a “person” from the first trimester. There has been an immense acceleration in understanding of early human development. The anatomy and physiology of embryonic development is a field where medicine exerts greatest impact on early pregnancy at present, and it opens fascinating aspects of embryonic differentiation. Clinical assessment of those stages of growth relies heavily on 3D/four-dimensional (4D) HDlive, one of the most promising forms of noninvasive diagnostics and embryological phenomena, once matters for textbooks are now routinely recorded with outstanding clarity. New advances deserve the adjective “breathtaking”, including 4D parallel study of the structural and functional early human development.
References
[1]Bonilla-Musoles F, Esquembre MJ, Bonilla F Jr, Raga F, Machado LE, Caballero O. First trimester. DSJUOG. 2014; in press.Search in Google Scholar
[2]Bonilla-Musoles F, Raga F, Castillo JC, Bonilla F Jr., Climent MT, Caballero O. High definition real-time ultrasound (HDLive) of embryonic and fetal malformations before week 16. DSJUOG. 2013;7:1–8.10.5005/jp-journals-10009-1266Search in Google Scholar
[3]Grigore M, Cojocaru C, Lazar T. The role of HD live technology in obstetrics and gynecology, present and future. DSJUOG. 2014; in press.10.5005/jp-journals-10009-1361Search in Google Scholar
[4]Hata T, Hanaoka U, Tenkumo C, Sato M, Tanaka H, Ishimura M. Three- and four-dimensional HDlive rendering images of normal and abnormal fetuses: pictorial essay. Arch Gynecol Obstet. 2012;286:1431–5.10.1007/s00404-012-2505-1Search in Google Scholar PubMed
[5]Kagan KO, Pintoffl K, Hoopmann M. First-trimester ultrasound images using HDlive. Ultrasound Obstet Gynecol. 2011;38:607.10.1002/uog.10112Search in Google Scholar PubMed
[6]Kurjak A, Azumendi G, Andonotopo W, Salihagic-Kadic A. Three- and four-dimensional ultrasonography for the structural and functional evaluation of the fetal face. Am J Obstet Gynecol. 2007;196:16–28.10.1016/j.ajog.2006.06.090Search in Google Scholar PubMed
[7]Kurjak A, Miskovic B, Stanojevic M, Amiel-Tison C, Ahmed B, Azumendi G, et al. New scoring system for fetal neurobehavior assessed by three- and four-dimensional sonography. J Perinat Med. 2008;36:73–81.10.1515/JPM.2008.007Search in Google Scholar PubMed
[8]Kurjak A, Pooh RK, Merce LT, Carrera JM, Salihagic-Kadic A, Andonotopo W. Structural and functional early human development assessed by three-dimensional (3D) and four-dimensional (4D) sonography. Fertil Steril. 2005;84:1285–99.10.1016/j.fertnstert.2005.03.084Search in Google Scholar PubMed
[9]Kurjak A, Pooh RK, Tikvica A, Stanojevic M, Miskovic B, Ahmed B, et al. Assessment of fetal neurobehavior by 3D/4D ultrasound. In: Pooh RK, Kurjak A, editors. Fetal neurology. New Delhi: Jaypee Brothers Medical Publishers; 2009. p. 221–85.10.5005/jp/books/10305_7Search in Google Scholar
[10]Pooh RK. 3D Sonoembryology. DSJUOG. 2011;5:7–15.10.5005/jp-journals-10009-1171Search in Google Scholar
[11]Pooh RK. Early detection of fetal abnormality. DSJUOG. 2013;7:46–50.10.5005/jp-journals-10009-1269Search in Google Scholar
[12]Pooh RK, Kurjak A. 3D/4D sonography moved prenatal diagnosis of fetal anomalies from the second to the first trimester of pregnancy. J Mater Fetal Neonatal Med. 2012;25:433–55.10.3109/14767058.2011.636107Search in Google Scholar PubMed
[13]Pooh RK, Shiota K, Kurjak A. Imaging of the human embryo with magnetic resonance imaging microscopy and high-resolution transvaginal 3-dimensional sonography: human embryology in the 21st century. Am J Obstet Gynecol. 2011;204:77.e1–16.10.1016/j.ajog.2010.07.028Search in Google Scholar PubMed
The authors stated that there are no conflicts of interest regarding the publication of this article.
©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Academy’s Corner
- Obstetrical Doppler: the evidence today
- Review article
- Fetal complications due to intrahepatic cholestasis of pregnancy
- Original articles – Obstetrics
- Pre-pregnancy obesity compromises obstetric and neonatal outcomes
- Novel application of three-dimensional HDlive imaging in prenatal diagnosis from the first trimester
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- Haemorrhagic and thrombotic complications in pregnant women with acquired and congenital cardiac disease
- Intrapartum ultrasound prior to Kristeller maneuver: an observational study
- Interinstitutional variations in mode of birth after a previous caesarean section: a cross-sectional study in six German hospitals
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- Original articles – Fetus
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- Original articles – Newborn
- Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study
- Antenatal testing in uncomplicated pregnancies: should testing be initiated after 40 or 41 weeks?
- Low total IgM values and high cytomegalovirus loads in the blood of newborns with symptomatic congenital cytomegalovirus infection
- Associated anomalies in congenital diaphragmatic hernia: perinatal characteristics and impact on postnatal survival
- The value of lipopolysaccharide binding protein for diagnosis of late-onset neonatal sepsis in very low birth weight infants
- Is there a stepwise increase in neonatal morbidities according to histological stage (or grade) of acute chorioamnionitis and funisitis?: effect of gestational age at delivery
- Commentary
- Thrombophilia testing in pregnancy: should we agree to disagree?
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Academy’s Corner
- Obstetrical Doppler: the evidence today
- Review article
- Fetal complications due to intrahepatic cholestasis of pregnancy
- Original articles – Obstetrics
- Pre-pregnancy obesity compromises obstetric and neonatal outcomes
- Novel application of three-dimensional HDlive imaging in prenatal diagnosis from the first trimester
- Placental gene expression of inflammatory markers and growth factors – a case control study of obese and normal weight women
- Haemorrhagic and thrombotic complications in pregnant women with acquired and congenital cardiac disease
- Intrapartum ultrasound prior to Kristeller maneuver: an observational study
- Interinstitutional variations in mode of birth after a previous caesarean section: a cross-sectional study in six German hospitals
- Use of the angle of progression on ultrasonography to predict spontaneous onset of labor within 7 days
- Study of the relationship in pregnant women between hepatitis B markers and a placenta positive for hepatitis B surface antigen
- Sarcoidosis and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 7 million births
- Original articles – Fetus
- MR imaging of the fetal brain at 1.5T and 3.0T field strengths: comparing specific absorption rate (SAR) and image quality
- Sex differences in the fetal heart rate variability indices of twins
- Original articles – Newborn
- Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study
- Antenatal testing in uncomplicated pregnancies: should testing be initiated after 40 or 41 weeks?
- Low total IgM values and high cytomegalovirus loads in the blood of newborns with symptomatic congenital cytomegalovirus infection
- Associated anomalies in congenital diaphragmatic hernia: perinatal characteristics and impact on postnatal survival
- The value of lipopolysaccharide binding protein for diagnosis of late-onset neonatal sepsis in very low birth weight infants
- Is there a stepwise increase in neonatal morbidities according to histological stage (or grade) of acute chorioamnionitis and funisitis?: effect of gestational age at delivery
- Commentary
- Thrombophilia testing in pregnancy: should we agree to disagree?
- Congress Calendar
- Congress Calendar
