Cytotoxic Effects of Curcumin in Human Retinal Pigment Epithelial Cells
Figure 3
Concentration-dependent effects of curcumin on the proliferation (A, B) and chemotaxis (C) of RPE cells.
The rate of BrdU incorporation was measured after a 24 h (A) and 96 h (B) incubation with the agents, respectively. The concentration of curcumin (in µM) is given in the bars. The effects were determined in the absence (control) and presence of PDGF (10 ng/ml). The vehicle control was made with ethanol (0.2%). Data are means ± SEM of 4–8 independent experiments carried out in triplicate using cells from different donors, and are expressed in percent of untreated control (100%). Significant differencevs. untreated control: *P<0.05; **P<0.01; ***P<0.001. Significant differencevs. PDGF control:•P<0.05;••P<0.01.