The Genome Sequence ofCaenorhabditis briggsae: A Platform for Comparative Genomics
Figure 1
Joint Refinement ofC. elegans andC. briggsae Gene Models:acy-4
When annotating theC. briggsae andC. elegans acy-4 orthologs, we chose the Genefinderce-acy-4 prediction and the Genefindercb-acy-4 prediction because, out of the 12 possible combinations of aC. briggsae and aC. elegans prediction, this pair shows the most similarity to each other. Coding sequence (CDS) conservation betweencb-acy-4 andce-acy-4 provides evidence for as many as 12 additional N-terminal exons in the Genefinderce-acy-4 prediction, as compared toT01C2.1, the WS77ce-acy-4 prediction. Subsequently, four of the additional N-terminal exons that were predicted by FGENESH and Genefinder were confirmed by new EST data (marked with asterisks).