1. Hua-Wei Chen1,3,
2. Xiu Chen1,3,
3. Su-Wan Oh1,
4. Maria J. Marinissen2,
5. J. Silvio Gutkind2, and
6. Steven X. Hou1,4

1. ¹The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA;²Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA

Abstract

The JAK/STAT signal transduction pathway controls numerous events inDrosophila melanogaster development. Receptors for the pathway have yet to be identified. Here we have identified aDrosophilagene that shows embryonic mutant phenotypes identical to those in thehopscotch(hop)/JAK kinase andmarelle(mrl)/Stat92e mutations. We named this genemaster of marelle(mom). Genetic analyses placemom's function betweenupd (the ligand) andhop. We further show that cultured cells transfected with themom gene bind UPD and activate the HOP/STAT92E signal transduction pathway.mom encodes a protein distantly related to the mammalian cytokine receptor family. These data show thatmom functions as a receptor of theDrosophilaJAK/STAT signal transduction pathway.

Keywords

• Drosophila
• JAK/STAT
• signal transduction
• cytokine receptor

Footnotes

• ↵3 These authors contributed equally to this work.

• ↵4 Corresponding author.

• E-MAILshou{at}mail.ncifcrf.gov; FAX (301) 846-6145.

• Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.955202.

• • Received October 19, 2001.
  • Accepted December 6, 2001.
• Cold Spring Harbor Laboratory Press

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