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RESEARCH REPORTS

Early social isolation increases persistence of alcohol-seeking behavior in alcohol-related contexts

Cortés-Patiño, Diana M.; Serrano, Catalina; Garcia-Mijares, Miriam

Author Information

Experimental Psychology Department, Institute of Psychology, University of São Paulo, São Paulo, Brazil

Present address: Diana M. Cortés-Patiño is now at University of San Buenaventura, Bogotá-Colombia.

Correspondence to Diana M. Cortés-Patiño, MS, Psychology Department, University of San Buenaventura, Carrera 8h # 172-20, Bogotá, Colombia 110141675 E-mails:[email protected],[email protected]

Received October 7, 2015

Accepted December 16, 2015

Behavioural Pharmacology27(2 and 3 - Special Issue):p 185-191, April 2016. |DOI:10.1097/FBP.0000000000000213

Abstract

Social conditions during rearing are well known to affect adult alcohol consumption, but few experiments have explored the effects of social conditions on behaviors that are related to alcohol dependence, such as the persistence of alcohol seeking. This study compared the effects of isolation (ISO) and interaction (INT) rearing on the persistence of alcohol-seeking behavior. Rats were trained to lever press for a solution of 10% alcohol diluted in water. They were then exposed to a two-component multiple schedule of reinforcement (baseline). Responses in one component were reinforced by a higher rate of alcohol delivery (rich component, variable interval 15 s) and responses in the other component were reinforced by a lower rate of delivery (lean component, variable interval 45 s). The persistence of lever pressing in the presence of each stimulus was then assessed during extinction. The results from baseline showed that response rates in rats in both groups were higher in the rich component than in the lean component, but ISO rats responded significantly more than INT rats in both components. The persistence of responding during extinction in ISO rats in both components was also higher than that in INT rats. The results show that effects of ISO are not restricted to alcohol consumption, but also affect persistence of alcohol-seeking behavior, which may reflect differences in the value of drug-related stimuli.

Copyright © 2016 YEAR Wolters Kluwer Health, Inc. All rights reserved.

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Behavioural Pharmacology27(2 and 3 - Special Issue):185-191, April 2016.
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