Organocatalysis—after the gold rush
* Corresponding authors
a Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark
E-mail:kaj@chem.au.dk
Abstract
The use ofsecondary amines as asymmetriccatalysts in transformations ofcarbonyl compounds has seen tremendous development in recent years. Going from sporadic reports of selected reactions, aminocatalysis can now be considered as one of the methods of choice for many asymmetric functionalizations ofcarbonyl compounds—primarily ofaldehydes andketones. These functionalizations have been published at a breathtaking pace over the last few years—during the “golden age” and “gold rush” of organocatalysis. Thistutorial review will firstly sketch the basic developments in organocatalysis, focussing especially on the use ofsecondary amines ascatalysts for the functionalization ofaldehydes and α,β-unsaturatedaldehydes, with emphasis on the mechanisms of the transformations and, secondly, outline recent trends within central areas of this research topic. Lastly, we will present our guesses as to where new developments might take organocatalysis in the years to come.
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- Article type
- Tutorial Review
- Submitted
- 23 Feb 2009
- First published
- 21 May 2009
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Organocatalysis—after the gold rush
S. Bertelsen and K. A. Jørgensen,Chem. Soc. Rev., 2009, 38, 2178DOI: 10.1039/B903816G
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