Selective guanine oxidation by UVB-irradiation in telomeric DNA

* Corresponding authors

a The Institute of Scientific and Industrial Research (SANKEN), Osaka University, Address Mihogaoka 8-1, Ibaraki, Japan
E-mail:kiyohiko@sanken.osaka-u.ac.jp
Fax: +81 6 6879 8499
Tel: +81 6 6879 8496

b The Institute of Scientific and Industrial Research (SANKEN), Osaka University, Address Mihogaoka 8-1, Ibaraki, Japan
E-mail:majima@sanken.osaka-u.ac.jp
Fax: +81 6 6879 8499
Tel: +81 6 6879 8495

Abstract

The combination of the transient absorption measurement and DNA damage quantification byHPLC clearly demonstrated the preferential excitation ofguanine and itsdecomposition in quadruplex DNA by UVB-irradiation.

Graphical abstract: Selective guanine oxidation by UVB-irradiation in telomeric DNA

Article information

Article type
Communication
Submitted
30 Nov 2004
Accepted
23 Dec 2004
First published
21 Jan 2005

Chem. Commun., 2005, 1476-1477

Selective guanineoxidation by UVB-irradiation in telomeric DNA

K. Kawai, M. Fujitsuka and T. Majima,Chem. Commun., 2005, 1476DOI: 10.1039/B418000C

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