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Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
- Dmitry I. Gabrilovich1 nAff2,
- Hailei L. Chen1,
- Khaled R. Girgis1,
- H. Thomas Cunningham1,
- Geralyn M. Meny1,
- Sorena Nadaf1 nAff2,
- Denise Kavanaugh1 &
- …
- David P. Carbone1 nAff2
Nature Medicinevolume 2, pages1096–1103 (1996)Cite this article
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AnErratum to this article was published on 01 November 1996
Abstract
Inadequate presentation of tumor antigens by host professional antigen–presenting cells (APCs), including dendritic cells (DCs), is one potential mechanism for the escape of tumors from the host immune system. Here, we show that human cancer cell lines release a soluble factor or factors that dramatically affect DC maturation from precursors without affecting the function of relatively mature DCs. One factor responsible for these effects was identified as vascular endothelial growth factor (VEGF). Thus, VEGF may play a broader role in the pathogenesis of cancer than was previously thought, and therapeutic blockade of VEGF action may improve prospects for immunotherapy as well as inhibit tumor neovasculature.
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Author information
Dmitry I. Gabrilovich, Sorena Nadaf & David P. Carbone
Present address: The Vanderbilt Cancer Center, Vanderbilt University School of Medicine, 649 Medical Research Building II, Nashville, Tennessee, 37232-6838, USA
Authors and Affiliations
Hamon Center for Therapeutic Oncology Research and the Department of Internal Medicine, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas, 75325, USA
Dmitry I. Gabrilovich, Hailei L. Chen, Khaled R. Girgis, H. Thomas Cunningham, Geralyn M. Meny, Sorena Nadaf, Denise Kavanaugh & David P. Carbone
- Dmitry I. Gabrilovich
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- Hailei L. Chen
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- H. Thomas Cunningham
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- Denise Kavanaugh
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Gabrilovich, D., Chen, H., Girgis, K.et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells.Nat Med2, 1096–1103 (1996). https://doi.org/10.1038/nm1096-1096
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