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Published:01 November 2002

Wnt signalling sees spots

Nature Cell Biologyvolume 4, pagesE249–E250 (2002)Cite this article

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The organization of signalling complexes represents the coalescence of cell biology and signal transduction. Recent work on Dishevelled (Dvl), a multifunctional component of the Wnt–Frizzled (Fz) signalling pathway, ascribes vesicle- and actin-binding properties to a single domain within the protein. This could represent a critical point for divergence of the Wnt signalling pathway.

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**Figure 1: Dvl has distinct functions.**

References

Wallingford, J. B., Fraser, S. E. & Harland, R. M.Dev. Cell6, 695–706 (2002).
Article Google Scholar
Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T. & Perrimon, N.Genes Dev.16, 2610–2622 (1998).
Article Google Scholar
Penton, A., Wodarz, A. & Nusse, R.Genetics161, 747–762 (2002).
CAS PubMed PubMed Central Google Scholar
Wallingford, J. B. et al.Nature405, 81–85 (2000).
Article CAS PubMed Google Scholar
Habas, R., Kato, Y. & He, X.Cell107, 843–854 (2001).
Article CAS PubMed Google Scholar
Tree, D. R., et al.Cell109, 371–381 (2002).
Article CAS PubMed Google Scholar
Wong, H. C. et al.Nature Struct. Biol.12, 1178–84 (2000).
Google Scholar
Khlebtsova, N., Hung, L. W., Henderson, K., Moon, R. & Earnest, T.Acta Crystallogr. D. Biol. Crystallogr.56, 212–214 (2000).
Article CAS PubMed Google Scholar
Axelrod, J. D.Genes Dev.15, 1182–1187 (2001).
CAS PubMed PubMed Central Google Scholar
Capelluto, D. G. S. et al.Nature419, 726–729 (2002).
Article CAS PubMed Google Scholar
Yanagawa, S., van Leeuwen, F., Wodarz,A., Klingensmith, J. & Nusse, R.Genes Dev.9, 1087–1097 (1995).
Article CAS PubMed Google Scholar
Torres, M. A. & Nelson, W. J.J. Cell Biol.149, 1433–1442 (2000).
Article CAS PubMed PubMed Central Google Scholar
Sun, T. Q. et al.Nature Cell Biol.3, 628–636 (2001).
Article CAS PubMed Google Scholar
Peters, J. M., McKay, R. M., McKay, J. P. & Graff, J. M.Nature401, 345–350 (1999).
Article CAS PubMed Google Scholar
Sakanaka, C., Leong, P., Xu, L., Harrison, S. D. & Williams, L. T.Proc. Natl Acad. Sci. USA96, 12548–12552 (1999).
Article CAS PubMed PubMed Central Google Scholar

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Authors and Affiliations

Department of Developmental Biology and the Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, 94305, CA, USA
Michael Povelones & Roel Nusse

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