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RNA interference
Naturevolume 418, pages244–251 (2002)Cite this article
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Abstract
A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.
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Acknowledgements
I thank members of the Hannon laboratory for critical reading of the manuscript; J. Duffy for help in preparation of the figures; D. Baulcombe, M. Tijsterman, R. Carthew and S. Prasanth for providing the images forFig. 1; fellow investigators who granted permission to discuss unpublished observations; and C. Mello and C. Sherr for providing motive and opportunity, respectively, for our early work on RNAi. G.J.H. is a Rita Allen Foundation scholar and is supported by an Innovator Award from the U.S. Army Breast Cancer Research Program. This work was supported in part by a grant from the NIH.
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Gregory J. Hannon
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Hannon, G. RNA interference.Nature418, 244–251 (2002). https://doi.org/10.1038/418244a
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