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Nature Cell Biology
  • Historical Perspective
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The superfamily of heptahelical receptors

Nature Cell Biologyvolume 2, pagesE133–E136 (2000)Cite this article

Abstract

Despite a growing appreciation of functional analogies between visual and hormonal signalling systems in the early 1980s, the discovery of the close structural relationship between rhodopsin and theβ2-adrenergic receptor, and of the existence of a larger ‘superfamily’ of such receptors, came as a total surprise. Here I provide a personal perspective on events leading up to and flowing from this exciting discovery that opened up a vast field of research.

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Acknowledgements

This work was supported in part by the National Institutes of Health Grant HL 16037.

Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute and Departments of Medicine (Cardiology) and Biochemistry, Duke University Medical centre, Durham, 27710, North Carolina, USA

    Robert J. Lefkowitz

Authors
  1. Robert J. Lefkowitz

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Correspondence toRobert J. Lefkowitz.

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