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Nature
  • Brief Communication
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Population genetics

Malaria susceptibility andCD36 mutation

Naturevolume 405, pages1015–1016 (2000)Cite this article

Abstract

A critical step in infection byPlasmodium falciparum, the microorganism that causes the most severe form of malaria, is the adhesion of parasitized red blood cells to capillary endothelium. The human protein CD36 is a major receptor forP. falciparum-infected red blood cells1,2 and may contribute to the disease by sequestering infected red blood cells1,2 and inhibiting the immune response to the parasite3. We have found that African populations contain an exceptionally high frequency of mutations in CD36. Unexpectedly, these mutations that cause CD36 deficiency are associated with susceptibility to severe malaria, suggesting that the presence of distinctCD36 mutations in Africans and Asians4,5,6 is due to some selection pressure other than malaria.

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References

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Author information

Authors and Affiliations

  1. Molecular Medicine Group, MRC Clinical Sciences Centre, and Imperial College Genetics and Genomics Research Institute, Hammersmith Hospital, London, W12 0NN, UK

    Timothy J. Aitman, Lisa D. Cooper, Penny J. Norsworthy, Faisal N. Wahid, Jennefer K. Gray & James Scott

  2. Blood Center of Southeastern Wisconsin, Medical College of Wisconsin, Milwaukee, 53201-2178, Wisconsin, USA

    Brian R. Curtis

  3. Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, London , WC1E 7HT, UK

    Paul M McKeigue

  4. MRC Laboratories, Fajara , The Gambia

    Dominic Kwiatkowski & Brian M. Greenwood

  5. KEMRI Coastal Research Unit, Kilifi, Kenya

    Robert W. Snow

  6. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

    Adrian V Hill

Authors
  1. Timothy J. Aitman

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  2. Lisa D. Cooper

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  3. Penny J. Norsworthy

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  4. Faisal N. Wahid

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  5. Jennefer K. Gray

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  6. Brian R. Curtis

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  7. Paul M McKeigue

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  8. Dominic Kwiatkowski

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  9. Brian M. Greenwood

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  10. Robert W. Snow

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  11. Adrian V Hill

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  12. James Scott

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Corresponding author

Correspondence toTimothy J. Aitman.

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