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A human retinoic acid receptor which belongs to the family of nuclear receptors
Naturevolume 330, pages444–450 (1987)Cite this article
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Abstract
A cDNA encoding a protein that binds retinoic acid with high affinity has been cloned. The protein is homologous to the receptors for steroid hormones, thyroid hormones and vitamin D3, and appears to be a retinoic acid-inducible {Tans-acting enhancer factor, suggesting that the molecular mechanisms of the effect ofretinoids (vitamin A) on embryonic development, differentiation and tumour cell growth are similar to those described for other members of this nuclear receptor family.
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References
1. Lotan, R. Biochim. Biophys. Ada 605, 33-91 (1980). 2. Chytil, F. Pharmacol. Rev. 36, 935-1005 (1984). 3. Roberts, A. B. & Sporn, M. B. in The Retinoids (eds Sporn, M. B., Roberts, A. B. & Goodman, D. S.) 209-286 (Academic, Florida, 1984). 4. Strickland, S. et al Cancer Res. 43, 5268-5272 (1983). 5. Shubeita, H. E., Sambrook, J. F. & McCormick, A. M. Proc. natn. Acad. Sci. U.S.A. 84, 5645-5649 (1987). 6. Haussler, M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 5525-5529 (1983). 7. Porter, S. B., Ong, D. E., Chytil, F. & Orgebin-Crist, M.-C. / Androl. 6, 197-212 (1985). 8. Maden, M. Trends Genet. 1, 103-107 (1985). 9. Maden, M. & Summerbell, D. J. Embryol. exp. Morph. 97, 239-250 (1986). 10. Thaller, C. & Eichele, G. Nature 327, 625-628 (1987). 38. 11. Wilde, S. M., Wedden, S. E. & Tickle, C. Development 100, 723-733 (1987). 12. Slack, J. M. W. Nature 327, 553-554 (1987). 13. Kurkinen, M., Barlow, D. P., Helfman, D. M., Williams, J. G. & Hogan, B. L. M. Nucleic Acids Res. 11, 6199-6209 (1983). 14. Williams, J. B. & Napoli, J. L. Proc. natn. Acad. Sci. U.S.A. 82, 4658-4662 (1985). 15. Wang, S.-Y., LaRosa, G. J. & Gudas, L. J. Devl Biol. 107, 75-86 (1985). 16. Alonso, A., Weber, T. & Jorcano, J. L. Roux's Arch. Devl. Biol. 196, 16-21 (1987). 17. Green, S. & Chambon, P. Nature 324, 615-617 (1986). 18. Barkai, U. & Sherman, M. I. J. Cell Biol. 104, 671-678 (1987). 19. Ong, D. E., Crow, J. A. & Chytil, F. /. bioL Chem. 257, 13385-13389 (1982). 20. Grippo, J. F. & Gudas, L. J. J. biol Chem. 262, 4492-4500 (1987). 21. Kato, M., Kato, K., Blaner, W. S., Chertow, B. S. & Goodman, D. S. Proc. natn. Acad. Sci. U.S.A. 82, 2488-2492(1985). 22. Wei, L. N., Mertz, J. R., Goodman, D. S. & Nguyen-Hu, M. C. Molec. Endocrin. 1, 526-534 50. (1987). 23. Takase, S., Ong, D. E. & Chytil, F. Arch. Biochem. Biophys. 247, 328-334 (1986). 24. Weinberger, C., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. Nature 318, 670-672 53. (1985). 25. Green, S. et al. Nature 320, 134-139 (1986). 26. Krust, A. et al. EMBO J. 5, 891-897 (1986). 27. Weinberger, C. et al. Nature 324, 641-646 (1986). 28. Thompson, C. C., Weinberger, C., Lebo, R. & Evans, R. M. Science 237, 1610-1614 (1987). 29. McDonnnell, D. P., Mangelsdorf, D.J., Pike, J. W., Haussler, M. R. & O'Malley, B. W. Science 235, 1214-1217 (1987). 30. Arriza, J. L. et al. Science 237, 268-275 (1987). 31. Green, S. & Chambon, P. Nature 325, 75-78 (1987). 32. Kumar, V. et al. Cell (in the press). 33. Enver, T. Nature 317, 385-386 (1985). 34. Green, S., Gronemeyer, H. & Chambon, P. in Growth Factors and Oncogenes in Breast Cancer (ed. Sluyser, M.) 7-28 (Horwood, Chichester, 1987). 35. Kumar, V., Green, S., Staub, A. & Chambon, P. EMBO J. 5, 2231-2236 (1986). 36. Gronemeyer, H. et al. EMBO J. (in the press). 37. Lacroix, A. & Lippman, M. E. J. din. Invest. 65, 586-591 (1980). 38. Ueda, H., Ono, M., Hagino, Y. & Kuwano, M. Cancer Res. 45, 3332-3338 (1985). 39. Govindan, M. V., Devic, M., Green, S., Gronemeyer, H. & Chambon, P. Nucleic Acids Res. 13,8293-8304(1985). 40. Hollenberg, S. M. et al. Nature 318, 635-641 (1985). 41. Misrahi, M. et al. Biochem. biophys. Res. Comm. 143, 740-748 (1987). 42. Hollenberg, S. M., Giguere, V., Segui, P. & Evans, R. M. Cell 49, 39-46 (1987). 43. Rusconi, S. & Yamamoto, K. R. EMBO J. 6, 1309-1315 (1987). 44. Dejean, A., Bougueleret, L., Grzeschik, K. H. & Tiollais, P. Nature 322, 70-72 (1986). 45. Jeltsch, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 83, 5424-5428 (1986). 46. Zahraoui, A. & Cuny, G. Eur. J. Biochem. 166, 63-69 (1987). 47. Mattei, M. G., Mattei, J. F., Petkovich, M. & Chambon, P. Hum. Genet, (submitted). 48. Gosden, J. R., Middleton, P. G., Rout, D. & De Angelis, C. Cytogenet. Cell Genet. 43, 150-153 (1986). 49. Jansson, M., Philipson, L. & Vennstromm, B. EMBO J. 2, 561-565 (1983). 50. Jetten, A. & De Luca, L. M. Biochem. biophys. Res. Comm. 114, 593-599 (1983). 51. McCue, P. A., Matthaei, K. I., Taketo, M. & Sherman, M. I. Devl Biol. 96, 416-426 (1983). 52. Wang, S.-Y. & Gudas, L. J. J. biol. Chem. 259, 5899-5906 (1984). 53. Lotan, R., Stolarsky, T. & Lotan, D. Cancer Res. 43, 2868-2875 (1983). 54. Debuire, B. et al. Science 224, 1456-1459 (1984). 55. Miesfeld, R. et al. Cell 46, 389-399 (1986). 56. Dente, L., Cesareni, G. & Cortese, R. Nucleic Acids Res. 11, 1645-1655 (1983). 57. Lin, H.-C., Lei, S.-P. & Wilcox, G. Analyt. Biochem. 147, 114-119 (1985).
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Authors and Affiliations
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologic Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, 11 rue Humann, 67085, Strasbourg-Cédex, France
Martin Petkovich, Nigel J. Brand, Andrée Krust & Pierre Chambon
- Martin Petkovich
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- Nigel J. Brand
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- Andrée Krust
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- Pierre Chambon
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Petkovich, M., Brand, N., Krust, A.et al. A human retinoic acid receptor which belongs to the family of nuclear receptors.Nature330, 444–450 (1987). https://doi.org/10.1038/330444a0
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