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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Naturevolume 304, pages596–602 (1983)Cite this article

Abstract

Transfection of embryo fibroblasts by a humanras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellularmyc gene or the gene for the polyoma large-T antigen is introduced together with theras gene.

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Authors and Affiliations

  1. Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02139, USA

    Hartmut Land, Luis F. Parada & Robert A. Weinberg

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  1. Hartmut Land

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  2. Luis F. Parada

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  3. Robert A. Weinberg

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Land, H., Parada, L. & Weinberg, R. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.Nature304, 596–602 (1983). https://doi.org/10.1038/304596a0

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