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High densities of benzodiazepine receptors in human cortical areas

Naturevolume 269, pages702–704 (1977)Cite this article

Abstract

THE presence of brain-specific benzodiazepine receptors in membranes from rat brain is now established1–4. Highly significant correlations between the affinities of various benzodiazepines for the benzodiazepine receptor site in rat brain on the one hand and clinically predictive pharmacological activities in several species on the other, strongly suggest that the benzodiazepine receptorin vitro is related to a physiologically relevant receptor for benzodiazepinesin vivo. We report here that benzodiazepine receptors are also present in the human brain, that the cerebral and cerebellar cortical regions contain the highest densities of binding sites and that the receptors in human brain are very similar to those in rat brain.

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Author information

Authors and Affiliations

  1. Psychopharmacologieal Research Laboratory, Dept. E., DK-4000, Roskilde

    C. BRAESTRUP

  2. University Institute of Pathological Anatomy, Copenhagen

    R. ALBRECHTSEN

  3. Research Laboratories, A/S Ferrosan, Sydmarken 1-5, 2860, Soeborg, Denmark

    R. F. SQUIRES

Authors
  1. C. BRAESTRUP

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  2. R. ALBRECHTSEN

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  3. R. F. SQUIRES

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BRAESTRUP, C., ALBRECHTSEN, R. & SQUIRES, R. High densities of benzodiazepine receptors in human cortical areas.Nature269, 702–704 (1977). https://doi.org/10.1038/269702a0

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