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ATM and breast cancer susceptibility
Oncogenevolume 25, pages5906–5911 (2006)Cite this article
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Abstract
ATM was originally identified by positional cloning as the gene that underlies the autosomal recessive condition ataxia-telangiectasia. The encoded protein plays a central role in the complex processes that repair DNA double-strand breaks. Nearly 20 years ago, epidemiological surveys of relatives of ataxia-telangiectasia cases suggested that female relatives were at modestly increased risk of breast cancer. Subsequently, many studies have tried to clarify the role ofATM in breast cancer susceptibility, but have produced inconclusive and/or inconsistent results. Recently, large epidemiological and molecular studies have finally provided conclusive evidence thatATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles.
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Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK
M Ahmed & N Rahman
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Ahmed, M., Rahman, N.ATM and breast cancer susceptibility.Oncogene25, 5906–5911 (2006). https://doi.org/10.1038/sj.onc.1209873
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