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Controlling escape from angiogenesis inhibitors
Nature Reviews Cancervolume 12, pages699–709 (2012)Cite this article
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Abstract
Selective inhibition of vascular endothelial growth factor (VEGF) increases the efficacy of chemotherapy and has beneficial effects on multiple advanced cancers, but response is often limited and the disease eventually progresses. Changes in the tumour microenvironment — hypoxia among them — that result from vascular pruning, suppressed angiogenesis and other consequences of VEGF inhibition can promote escape and tumour progression. New therapeutic approaches that target pathways that are involved in the escape mechanisms add the benefits of blocking tumour progression to those of slowing tumour growth by inhibiting angiogenesis.
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Acknowledgements
This work was supported in part by US National Institutes of Health (NIH) grants HL24136 and HL59157 from the National Heart, Lung, and Blood Institute, and funding from AngelWorks Foundation (to D.McD.).
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Cardiovascular Research Institute and Department of Anatomy, Barbara Sennino and Donald M. McDonald are at The UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), 513 Parnassus Avenue, Room S1349, San Francisco, California 94143–0452, USA,
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Sennino, B., McDonald, D. Controlling escape from angiogenesis inhibitors.Nat Rev Cancer12, 699–709 (2012). https://doi.org/10.1038/nrc3366
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