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Nature Immunology
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IL-28, IL-29 and their class II cytokine receptor IL-28R

Nature Immunologyvolume 4, pages63–68 (2003)Cite this article

Abstract

Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor β (IL-10Rβ) and an orphan class II receptor chain, designated IL-28Rα. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.

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Figure 1: Sequence alignment of IL-28 and IL-29.
Figure 2: RNA expression of IL-28 and IL-29.
Figure 3: IFN-like activities of IL-28 and IL-29.
Figure 4: Binding of IL-28A and IL-29.
Figure 5: Alignment of IL-28Rαv1 and IL-22Rα2.
Figure 6: IL-28Rα RNA expression analysis.
Figure 7: Requirement of IL-28Rα and IL-10Rβ for functional signaling.

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GenBank/EMBL/DDBJ

Protein Data Bank

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Acknowledgements

We thank P. O'Hara, R. Adams and D. Sawislak for project advice.

Author information

Author notes

  1. Paul Sheppard, Wayne Kindsvogel and Wenfeng Xu: These authors contributed equally to this work.

Authors and Affiliations

  1. ZymoGenetics, Inc., 1201 Eastlake Avenue E., Seattle, 98102, WA, USA

    Paul Sheppard, Wayne Kindsvogel, Wenfeng Xu, Katherine Henderson, Stacy Schlutsmeyer, Theodore E. Whitmore, Rolf Kuestner, Ursula Garrigues, Carl Birks, Jenny Roraback, Craig Ostrander, Dennis Dong, Jinu Shin, Scott Presnell, Brian Fox, Betty Haldeman, Emily Cooper, David Taft, Teresa Gilbert, Francis J. Grant, Monica Tackett, William Krivan, Gary McKnight, Chris Clegg, Don Foster & Kevin M. Klucher

Authors
  1. Paul Sheppard
  2. Wayne Kindsvogel
  3. Wenfeng Xu
  4. Katherine Henderson
  5. Stacy Schlutsmeyer
  6. Theodore E. Whitmore
  7. Rolf Kuestner
  8. Ursula Garrigues
  9. Carl Birks
  10. Jenny Roraback
  11. Craig Ostrander
  12. Dennis Dong
  13. Jinu Shin
  14. Scott Presnell
  15. Brian Fox
  16. Betty Haldeman
  17. Emily Cooper
  18. David Taft
  19. Teresa Gilbert
  20. Francis J. Grant
  21. Monica Tackett
  22. William Krivan
  23. Gary McKnight
  24. Chris Clegg
  25. Don Foster
  26. Kevin M. Klucher

Corresponding author

Correspondence toKevin M. Klucher.

Ethics declarations

Competing interests

All the authors of the article are employees of ZymoGenetics, Inc. and as such receive salaries and shares of stock in ZymoGenetics.

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Sheppard, P., Kindsvogel, W., Xu, W.et al. IL-28, IL-29 and their class II cytokine receptor IL-28R.Nat Immunol4, 63–68 (2003). https://doi.org/10.1038/ni873

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