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The TREM receptor family and signal integration
Nature Immunologyvolume 7, pages1266–1273 (2006)Cite this article
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Abstract
TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.
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Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, 63110, Missouri, USA
Julia Klesney-Tait, Isaiah R Turnbull & Marco Colonna
- Julia Klesney-Tait
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- Isaiah R Turnbull
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- Marco Colonna
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Correspondence toMarco Colonna.
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M.C. has stock options in BioXell, which works on TREM proteins
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Klesney-Tait, J., Turnbull, I. & Colonna, M. The TREM receptor family and signal integration.Nat Immunol7, 1266–1273 (2006). https://doi.org/10.1038/ni1411
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