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Nature Immunology
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Alternative lifestyles of T cells

Nature Immunologyvolume 9pages1323–1325 (2008)Cite this article

T cells are intrinsically more malleable than previously thought. Two studies now show that existing T helper type 2 cells can be converted into alternative CD4+ T helper cells that coexpress interleukins 9 and 10.

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Figure 1: Functional plasticity of T cells: the cytokine environment controls the lineage conversion of a T helper subset.

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Author information

Authors and Affiliations

  1. Cristina M. Tato and Daniel J. Cua are with Schering-Plough Biopharma, DNAX Research, Palo Alto, California, 94304 USA. daniel.cua@spcorp.com,

    Cristina M Tato & Daniel J Cua

Authors
  1. Cristina M Tato

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  2. Daniel J Cua

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Associated content

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3 effector T cells

  • Valérie Dardalhon
  • Amit Awasthi
  • Vijay K Kuchroo
Nature ImmunologyArticle

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