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When ligand becomes receptor—tolerancevia B7 signaling on DCs
Nature Immunologyvolume 3, pages1056–1057 (2002)Cite this article
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CTLA-4–Ig is used to block the costimulation of T cells to interfere with their activation. This reagent may actually be working by provoking DCs to catabolize tryptophan, thereby depriving T cells and contributing to their demise.
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Erik B. Finger
Present address: Department of Surgery, Massachusetts General Hospital, Boston, MA, 02114, USA
Authors and Affiliations
UCSF Diabetes Center, UCSF School of Medicine, San Francisco, 94143, CA, USA
Erik B. Finger & Jeffrey A. Bluestone
- Erik B. Finger
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- Jeffrey A. Bluestone
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Correspondence toJeffrey A. Bluestone.
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Finger, E., Bluestone, J. When ligand becomes receptor—tolerancevia B7 signaling on DCs.Nat Immunol3, 1056–1057 (2002). https://doi.org/10.1038/ni1102-1056
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