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Homer: a protein that selectively binds metabotropic glutamate receptors

Naturevolume 386pages284–288 (1997)Cite this article

Abstract

Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors1 and ion channels2. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with them. Here we report a novel dendritic protein, Homer, that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors. Homer is highly divergent from known PDZ proteins and seems to represent a novel family. TheHomer gene is also distinct from members of the PDZ family in that its expression is regulated as an immediate early gene and is dynamically responsive to physiological synaptic activity, particularly during cortical development. This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling.

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Author information

Authors and Affiliations

  1. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    P. R. Brakeman, A. A. Lanahan, Richard O'Brien, R. L. Huganir & P. F. Worley

  2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Richard O'Brien & P. F. Worley

  3. Department of Biochemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    R. L. Huganir

  4. Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    R. L. Huganir

  5. National Institutes of Health, Bethesda, Maryland, 20892, USA

    K. Roche

  6. Department of Psychology and Neurology and Division of Neuronal Systems, Memory, and Aging, University of Arizona, Tucson, Arizona, 84724, USA

    C. A. Barnes

Authors
  1. P. R. Brakeman
  2. A. A. Lanahan
  3. Richard O'Brien
  4. K. Roche
  5. C. A. Barnes
  6. R. L. Huganir
  7. P. F. Worley

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Brakeman, P., Lanahan, A., O'Brien, R.et al. Homer: a protein that selectively binds metabotropic glutamate receptors.Nature386, 284–288 (1997). https://doi.org/10.1038/386284a0

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