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Tissue ablation by a free-electron laser tuned to the amide II band

Naturevolume 371, pages416–419 (1994)Cite this article

Abstract

EFFORTS to ablate soft tissue with conventional lasers have been limited by collateral damage and by concern over potential photochemical effects1–5. Motivated by the thermal-confinement model6, past infrared investigations targeted the OH-stretch mode of water with fast pulses from lasers emitting near 3,000 nm (refs 1,7–9). What does a free-electron laser offer for the investigation of tissue ablation? Operating at non-photochemical single-photon energies, these infrared sources can produce trains of picosecond pulses tunable to the vibrational modes of proteins, lipids and/or water. We report here that targeting free-electron laser radiation to the amide II band of proteins leads to tissue ablation characterized by minimal collateral damage while maintaining a substantial ablation rate. To account for these observations we propose a novel ablation mechanism based on compromising tissue through resonant denaturation of structural proteins.

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Author information

Authors and Affiliations

  1. Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, 37235, USA

    Glenn Edwards, Lou Reinisch, Bruce Johnson, Marcus Mendenhall & Jerri Tribble

  2. Departments of Ophthalmology and Visual Sciences,

    Regan Logan & Denis O'Day

  3. Neurosurgery,

    Michael Copeland

  4. Otolaryngology,

    Glenn Edwards, Lou Reinisch, Robert Maciunas, Robert Ossoff & Jay Werkhaven

  5. Pathology, Vanderbilt University Medical School, Nashville, Tennessee, 37232, USA

    Jeffrey Davidson

Authors
  1. Glenn Edwards
  2. Regan Logan
  3. Michael Copeland
  4. Lou Reinisch
  5. Jeffrey Davidson
  6. Bruce Johnson
  7. Robert Maciunas
  8. Marcus Mendenhall
  9. Robert Ossoff
  10. Jerri Tribble
  11. Jay Werkhaven
  12. Denis O'Day

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Edwards, G., Logan, R., Copeland, M.et al. Tissue ablation by a free-electron laser tuned to the amide II band.Nature371, 416–419 (1994). https://doi.org/10.1038/371416a0

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