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Conservation of position and exclusive expression of mouseXist from the inactive X chromosome

Naturevolume 351, pages329–331 (1991)Cite this article

Abstract

X-CHROMOSOME inactivation in mammals is a regulatory phenomenon whereby one of the two X chromosomes in female cells is genetically inactivated, resulting in dosage compensation for X-linked genes between males and females1. In both man and mouse, X-chromosome inactivation is thought to proceed from a singlecis-acting switch region or inactivation centre (XlC/Xic)2–5. In the human, XIC has been mapped to band Xql3 (ref. 6) and in the mouse to band XD (ref. 7), and comparative mapping has shown that the XIC regions in the two species are syntenic8. The recently described humanXIST gene maps to the XIC region6 and seems to be expressed only from the inactive X chromosome9. We report here that the mouseXist gene maps to the Xic region of the mouse X chromosome and, using an interspecificMus spretus/Mus musculus domesticus F1 hybrid mouse carrying the T(X; 16)16H translocation, show thatXist is exclusively expressed from the inactive X chromosome. Conservation between man and mouse of chromosomal position and unique expression exclusively from the inactive X chromosome lends support to the hypothesis thatXIST and its mouse homologue are involved in X-chromosome inactivation.

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References

  1. Lyon, M. F.Nature190, 37–373 (1961).

    Article  Google Scholar 

  2. Russell, L. B.Science140, 976–978 (1963).

    Article ADS CAS  Google Scholar 

  3. Cattanach, B. M.A. Rev. Genet9, 1–18 (1975).

    Article CAS  Google Scholar 

  4. Mattei, M. G., Mattei, J. F., Vidal, I. & Giraud, F.Hum. Genet.56, 401–408 (1981).

    Article CAS  Google Scholar 

  5. Therman, G., Sarto, G. E. & Patau, K.,Chromosoma44, 361–366 (1974).

    Article CAS  Google Scholar 

  6. Brown, C. J.et al.Nature349, 82–84 (1991).

    Article ADS CAS  Google Scholar 

  7. Rastan, S. & Robertson, E. J.J. Embryol. exp. Morph.90, 379–388 (1985).

    CAS PubMed  Google Scholar 

  8. Keer, J. T.et al.Genomics7, 566–572 (1990).

    Article CAS  Google Scholar 

  9. Brown, C. J.et al.Nature349, 38–44 (1991).

    Article ADS CAS  Google Scholar 

  10. Brockdorff, N.et al.Genomics10, 17–22 (1991).

    Article CAS  Google Scholar 

  11. Cattanach, B. M., Rasberry, C. & Andrews, S. J.Mouse News Letter83, 165 (1989).

    Google Scholar 

  12. Rastan, S. & Brown, S. D. M.Genet. Res.56, 99–106 (1990).

    Article CAS  Google Scholar 

  13. Cattanach, B. M. & Papworth, D.Genet. Res.38, 57–70 (1981).

    Article CAS  Google Scholar 

  14. Johnston, P. G. & Cattanach, B. M.Genet. Res.37, 151–160 (1981).

    Article CAS  Google Scholar 

  15. Ashworth, A., Rastan, S., Lovell-Badge, R. & Kay, G.Nature (in the press).

  16. Lyon, M. F., Searle, A. G., Ford, C. E. & Ohno, S.Cytogenetics3, 306–323 (1964).

    Article CAS  Google Scholar 

  17. Brockdorff, N., Montague, M., Smith, S. & Rastan, S.Genomics7, 573–578 (1990).

    Article CAS  Google Scholar 

  18. Cattanach, B. M.et al.Cytogenet. Cell Genet. (in the press).

  19. Brockdorff, N., Kay, G., Cattanach, B. M. & Rastan, S.Mammalian Genome (in the press).

  20. Chirgwin, J. M.et al.Biochemistry18, 5294–5299 (1979).

    Article CAS  Google Scholar 

  21. Sambrook, J., Fritsch, E. F. & Maniatis, T.Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory Press, New York 1989).

    Google Scholar 

  22. Minty, A. J.et al.J. biol. Chem.256, 1008–1014 (1981).

    CAS PubMed  Google Scholar 

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Author information

Author notes

  1. Alan Ashworth: Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, UK

  2. Sohaila Rastan: To whom correspondence should be addressed

Authors and Affiliations

  1. Section of Comparative Biology, MRC Clinical Research Centre, Harrow, HA1 3UJ, UK

    Neil Brockdorff, Alan Ashworth, Graham F. Kay, Penny Cooper, Sandy Smith, Veronica M. McCabe, Dominic P. Norris, Graeme D. Penny, Dipika Patel & Sohaila Rastan

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  1. Neil Brockdorff

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  2. Alan Ashworth

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  3. Graham F. Kay

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  4. Penny Cooper

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  5. Sandy Smith

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  6. Veronica M. McCabe

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  7. Dominic P. Norris

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  8. Graeme D. Penny

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  9. Dipika Patel

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  10. Sohaila Rastan

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Brockdorff, N., Ashworth, A., Kay, G.et al. Conservation of position and exclusive expression of mouseXist from the inactive X chromosome.Nature351, 329–331 (1991). https://doi.org/10.1038/351329a0

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