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Lethality and centrality in protein networks
Naturevolume 411, pages41–42 (2001)Cite this article
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The most highly connected proteins in the cell are the most important for its survival.
Abstract
Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules1,2. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in the yeastSaccharomyces cerevisiae is affected to a large extent by the topological position of its protein product in the complex hierarchical web of molecular interactions.
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Authors and Affiliations
Department of Physics, University of Notre Dame, Notre Dame, 46556, Indiana, USA
H. Jeong & A.-L. Barabási
Department of Pathology, Northwestern University Medical School, Chicago, 60611, Illinois, USA
S. P. Mason & Z. N. Oltvai
- H. Jeong
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- S. P. Mason
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- A.-L. Barabási
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- Z. N. Oltvai
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Correspondence toA.-L. Barabási orZ. N. Oltvai.
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Jeong, H., Mason, S., Barabási, AL.et al. Lethality and centrality in protein networks.Nature411, 41–42 (2001). https://doi.org/10.1038/35075138
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