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Molecular phylogenetics and the origins of placental mammals

Naturevolume 409, pages614–618 (2001)Cite this article

Abstract

The precise hierarchy of ancient divergence events that led to the present assemblage of modern placental mammals has been an area of controversy among morphologists, palaeontologists and molecular evolutionists. Here we address the potential weaknesses of limited character and taxon sampling in a comprehensive molecular phylogenetic analysis of 64 species sampled across all extant orders of placental mammals. We examined sequence variation in 18 homologous gene segments (including nearly 10,000 base pairs) that were selected for maximal phylogenetic informativeness in resolving the hierarchy of early mammalian divergence. Phylogenetic analyses identify four primary superordinal clades: (I) Afrotheria (elephants, manatees, hyraxes, tenrecs, aardvark and elephant shrews); (II) Xenarthra (sloths, anteaters and armadillos); (III) Glires (rodents and lagomorphs), as a sister taxon to primates, flying lemurs and tree shrews; and (IV) the remaining orders of placental mammals (cetaceans, artiodactyls, perissodactyls, carnivores, pangolins, bats and core insectivores). Our results provide new insight into the pattern of the early placental mammal radiation.

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Figure 1: Phylogenetic relationships among 64 placental mammals and two marsupials based on analysis of 9,779 bp from 15 nuclear and three mtDNA genes.

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Acknowledgements

We thank D. Hirschmann, M. Houck, R. Montali, R. Baker, G. Harris, K. Helgen, A. L. Roca, M. Roelke-Parker, A. Grafodatsky, O. Serov and T. Oleksyk for help in obtaining samples and technical assistance, and M. Smith and M. Dean for helpful suggestions. We also thank the NCI Frederick Molecular Technology Center for technical support, and the Advanced Biomedical Computer Center for computational assistance. All tissue samples were obtained with appropriate permits (CITES) issued to the National Cancer Institute, National Institutes of Health (principal officer, S.J.O). Y.P.Z. is supported by the Natural Science Foundation of China and Chinese Academy of Sciences. E.E. is supported by Conselho Nacional de Desenvolvimento Científico e Tecnológíco (CNPq), Brazil.

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Author notes

  1. William J. Murphy, Eduardo Eizirik and Oliver A. Ryder: These authors contributed equally to this work

Authors and Affiliations

  1. Laboratory of Genomic Diversity, National Cancer Institute, Frederick, 21702, Maryland, USA

    William J. Murphy, Eduardo Eizirik, Warren E. Johnson & Stephen J. O'Brien

  2. Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China

    Ya Ping Zhang

  3. Center for Reproduction of Endangered Species, Zoological Society of San Diego, San Diego, 92112, California, USA

    Oliver A. Ryder

  4. Department of Biology, University of Maryland, College Park, 20742, Maryland, USA

    Eduardo Eizirik

Authors
  1. William J. Murphy

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  2. Eduardo Eizirik

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  3. Warren E. Johnson

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  4. Ya Ping Zhang

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  5. Oliver A. Ryder

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  6. Stephen J. O'Brien

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Corresponding author

Correspondence toStephen J. O'Brien.

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Murphy, W., Eizirik, E., Johnson, W.et al. Molecular phylogenetics and the origins of placental mammals.Nature409, 614–618 (2001). https://doi.org/10.1038/35054550

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