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A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
- Carolyn J. Brown1,
- Andrea Ballabio1 na1,
- James L. Rupert1,
- Ronald G. Lafreniere1,
- Markus Grompe1 na1,
- Rossana Tonlorenzi1 na1 &
- …
- Huntington F. Willard1 na2
Naturevolume 349, pages38–44 (1991)Cite this article
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Abstract
X-chromosome inactivation results in thecis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern—transcripts are detected only from the inactive X chromosome (Xi) and not from the active X chromosome (Xa). This gene, calledXIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation.
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Author information
Andrea Ballabio, Markus Grompe and Rossana Tonlorenzi: Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Huntington F. Willard: To whom correspondence should be addressed.
Authors and Affiliations
Department of Genetics, Stanford University School of Medicine, Stanford, California, 94305, USA
Carolyn J. Brown, Andrea Ballabio, James L. Rupert, Ronald G. Lafreniere, Markus Grompe, Rossana Tonlorenzi & Huntington F. Willard
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- Andrea Ballabio
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- James L. Rupert
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- Ronald G. Lafreniere
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- Markus Grompe
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- Rossana Tonlorenzi
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- Huntington F. Willard
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Brown, C., Ballabio, A., Rupert, J.et al. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome.Nature349, 38–44 (1991). https://doi.org/10.1038/349038a0
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