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Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyte
- Steven Porcelli1,2,
- Michael B. Brenner1,2,
- Julia L. Greenstein7,
- Cox Terhorst3,5,
- Steven P. Balk3,6 &
- …
- Paul A. Bleicher3,4
Naturevolume 341, pages447–450 (1989)Cite this article
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Abstract
HUMAN cluster-of-differentiation 1 (CD1) is a family of cell surface glycoproteins of unknown function expressed on immature thymocytes, epidermal Langerhans cells and a subset of B lymphocytes1–3. Three homologous proteins, CD la, b and c, have been defined serologically4, and the CD1 gene locus on human chromosome 1 contains five potential CD1 genes5. Analysis of the predicted amino-acid sequences of CD1 molecules reveals a low but significant level of homology to major histocompatibility complex (MHC) class I and class II molecules5,6, and, like MHC class I molecules, CD1 molecules are associated non-covalently with (β2-microglobulin7. These structural similarities to known antigen-presenting molecules, together with the expression of CD1 on cells capable of antigen presentation, suggest a role for CD1 molecules in antigen recognition by T cells. Here we demonstrate the specific recognition of CDla by a CD4−CD8− αβ T-cell receptor (TCR) expressing cytolytic T lymphocyte (CTL) line and the specific recognition of CD1c by a CD4−CD8>minus;γδTCR CTL line. The interaction of GDI-specific CTLs with CD1+ target cells appeared to involve the CD3–TCR complex, and did not show evidence of MHC restriction. These results suggest that for a subset of T cells, GDI molecules serve a function analogous to that of MHG class I and II molecules.
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Authors and Affiliations
Laboratory of Immunochemistry, Dana-Farber Cancer Institute,
Steven Porcelli & Michael B. Brenner
Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA
Steven Porcelli & Michael B. Brenner
Laboratory of Molecular Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, USA
Cox Terhorst, Steven P. Balk & Paul A. Bleicher
Department of Dermatology, Harvard Medical School, Boston, Massachusetts, 02115, USA
Paul A. Bleicher
Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115, USA
Cox Terhorst
Department of Hematology and Oncology, Beth Israel Hospital, Boston, Massachusetts, 02115, USA
Steven P. Balk
ImmuLogic Pharmaceutical Corp, Cambridge, Massachusetts, 02139, USA
Julia L. Greenstein
- Steven Porcelli
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- Michael B. Brenner
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- Cox Terhorst
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- Steven P. Balk
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- Paul A. Bleicher
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Porcelli, S., Brenner, M., Greenstein, J.et al. Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyte.Nature341, 447–450 (1989). https://doi.org/10.1038/341447a0
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