Movatterモバイル変換

[0]ホーム
URL:

Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

Nature
  • Article
  • Published:

A different genetic code in human mitochondria

Naturevolume 282, pages189–194 (1979)Cite this article

Abstract

Comparison of the human mitochrondrial DNA sequence of the cytochrome oxidase subunit II gene and the sequence of the corresponding beef heart protein shows that UGA is used as a tryptophan codon and not as a termination codon and suggests that AU A may be a methionine and not an isoleucine codon. The cytochrome oxidase II gene is contiguous at its 5′ end with a tRNAAsp gene and there are only 25 bases at its 3′ end before a tRNALys gene. These tRNAs are different from all other known tRNA sequences.

This is a preview of subscription content,access via your institution

Access options

Access through your institution

Subscription info for Japanese customers

We have a dedicated website for our Japanese customers. Please go tonatureasia.com to subscribe to this journal.

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

￥ 4,980

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Steffens, G. J. & Buse, G.Hoppe-Seyler's Z. physiol. Chem.360, 613 (1979).

    CAS PubMed  Google Scholar 

  2. Angerer, L., Davidson, N., Murphy, W., Lynch, D. C. & Attardi, G.Cell9, 81 (1976).

    Article CAS  Google Scholar 

  3. Ojala, D. & Attardi, G.Plasmid1, 78 (1977).

    Article CAS  Google Scholar 

  4. Lynch, D. C. & Attardi, G.J. molec. Biol.102, 125 (1976).

    Article CAS  Google Scholar 

  5. Hare, J., Ching, E. & Attardi, G. (in preparation).

  6. Borst, P.Trends biochem. Sci.2, 31 (1977).

    Article CAS  Google Scholar 

  7. Attardi, G.et al.Proc. ICN-UCLA Meet. Extrachromosomal DNA, March 1979 (in the press).

    Google Scholar 

  8. Aloni, Y. & Attardi, G.Proc. natn. Acad. Sci. U.S.A.68, 1957 (1971).

    Article  Google Scholar 

  9. Murphy, W., Attardi, B., Tu, C. & Attardi, G.J. molec. Biol.99, 809 (1975).

    Article CAS  Google Scholar 

  10. Almaric, F., Merkel, C., Gelfand, R. & Attardi, G.J. molec. Biol.118, 1 (1978).

    Article  Google Scholar 

  11. Sanger, F., Nicklen, S. & Coulson, A. R.Proc. natn. Acad. Sci. U.S.A.74, 5463 (1977).

    Article ADS CAS  Google Scholar 

  12. Smith, A. J. H.6, 831 (1979).

  13. Staden, R.Nucleic Acids Res.5, 1013 (1978).

    Article CAS  Google Scholar 

  14. Sprinzl, M., Grüter, F. & Gauss, D. H.Nucleic Acids Res. Spec. Suppl., r15 (1979).

    Google Scholar 

  15. Ladner, J. E.et al.Proc. natn. Acad. Sci. U.S.A.72, 4414 (1975).

    Article ADS CAS  Google Scholar 

  16. Kim, S. H.et al.Science185, 435 (1974).

    Article ADS CAS  Google Scholar 

  17. Hirsh, D.J. molec. Biol.58, 439 (1971).

    Article CAS  Google Scholar 

  18. Keith, G., Roy, A., Ebel, J. P. & Dirheimer, G.Biochimie54, 1404 (1972).

    Google Scholar 

  19. Harada, F., Sawyer, R. C. & Dahlberg, J. E.J. biol. Chem.250, 3487 (1975).

    CAS PubMed  Google Scholar 

  20. Chan, T. S. & Green, A.J. molec. Biol.49, 231 (1970).

    Article CAS  Google Scholar 

  21. Hirsh, D. & Gold, L.J. molec. Biol.58, 459 (1971).

    Article CAS  Google Scholar 

  22. Katz, E. thesis, Cambridge Univ. (1969).

  23. Roth, J. R.J. Bact.102, 467 (1970).

    CAS PubMed  Google Scholar 

  24. Wiener, A. M. & Weber, K.Nature new Biol.234, 206 (1971).

    Article  Google Scholar 

  25. Wiener, A. M. & Weber, K.J. molec. Biol.80, 837 (1973).

    Article  Google Scholar 

  26. Crick, F. H. C.J. molec. Biol.19, 548 (1966).

    Article CAS  Google Scholar 

  27. Fox, T. D.Proc. natn. Acad. Sci. U.S.A. (in the press).

  28. Beaudet, A. L. & Caskey, C. T.Proc. natn. Acad. Sci. U.S.A.68, 619 (1971).

    Article ADS CAS  Google Scholar 

  29. Scolnick, E., Tompkins, R., Caskey, T. & Nirenberg, M.Proc. natn. Acad. Sci. U.S.A.61, 768 (1968).

    Article ADS CAS  Google Scholar 

  30. Sebald, W. & Wachter, E. in29th Mosbacher Colloqu. Energy Conservation in Biological Membranes (eds Schafer, G. & Klingenberg, M. 228, (Springer, Berlin, 1978).

    Book  Google Scholar 

  31. Hensgens, L. A. M., Grivell, L. A., Borst, P. & Bos, J. L.Proc. natn. Acad. Sci. U.S.A.76, 1663 (1979).

    Article ADS CAS  Google Scholar 

  32. Aujame, L. & Freeman, K. B.Nucleic Acids Res.6, 455 (1979).

    Article CAS  Google Scholar 

  33. Mitra, S. K., Lustig, F., Åkesson, B., Lagerkvist, U. & Strid, L.J. biol. Chem.252, 471 (1977).

    CAS PubMed  Google Scholar 

  34. Lagerkvist, U.Proc. natn. Acad. Sci. U.S.A.75, 1759 (1978).

    Article ADS CAS  Google Scholar 

  35. Shine, J. & Dalgarno, L.Eur. J. Biochem.57, 221 (1975).

    Article CAS  Google Scholar 

  36. Steitz, J. A. & Jakes, K.Proc. natn. Acad. Sci. U.S.A.72, 4734 (1975).

    Article ADS CAS  Google Scholar 

  37. Hagenbuchle, O., Santer, M. & Steitz, J. A.Cell13, 551 (1978).

    Article CAS  Google Scholar 

  38. Sanger, F.et al.Nature265, 687 (1977).

    Article ADS CAS  Google Scholar 

  39. Fiers, W.et al.Nature273, 113 (1978).

    Article ADS CAS  Google Scholar 

  40. Reddy, V. B.et al.Science200, 494 (1978).

    Article ADS CAS  Google Scholar 

  41. Macino, G., Coruzzi, G., Nobrega, F. G., Li, M. & Tzagoloff, A.Proc. natn. Acad. Sci. U.S.A.76, 3784 (1979).

    Article ADS CAS  Google Scholar 

  42. Drouin, J.J. molec. Biol. (submitted).

  43. Brown, W. M. & Vinograd, J.Proc. natn. Acad. Sci. U.S.A.71, 4617 (1974).

    Article ADS CAS  Google Scholar 

  44. Robberson, D. L., Clayton, D. A. & Morrow, J. F.Proc. natn. Acad. Sci. U.S.A.71, 4447 (1974).

    Article ADS CAS  Google Scholar 

  45. Crews, S., Ojala, D., Posakany, J., Nishiguchi, J. & Attardi, G.Nature277, 192 (1979).

    Article ADS CAS  Google Scholar 

  46. Sanger, F. & Coulson, A. R.FEBS Lett.87, 107 (1978).

    Article CAS  Google Scholar 

Download references

Author information

Author notes

  1. J. Drouin

    Present address: Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94143

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK

    B. G. Barrell, A. T. Bankier & J. Drouin

Authors
  1. B. G. Barrell
  2. A. T. Bankier
  3. J. Drouin

Rights and permissions

About this article

Cite this article

Barrell, B., Bankier, A. & Drouin, J. A different genetic code in human mitochondria.Nature282, 189–194 (1979). https://doi.org/10.1038/282189a0

Download citation

This article is cited by

Access through your institution
Buy or subscribe

Advertisement

Search

Advanced search

Quick links

Nature Briefing

Sign up for theNature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox.Sign up for Nature Briefing
[8]ページ先頭
©2009-2026 Movatter.jp