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Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart
Naturevolume 262, pages615–617 (1976)Cite this article
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Abstract
THE regulation of contractile activity in cardiac muscle by changes in the intracellular Ca2+ concentration involves the regulatory protein system, consisting of tropomyosin and the troponin complex that is located in the I filament. Although the regulatory protein system of cardiac muscle is essentially similar in function to that of skeletal muscle, the components differ in the two tissues. Cardiac tropomyosin consists principally ofα subunits, whereas the skeletal protein is composed ofα andβ subunits1. Troponin I, troponin C and troponin T are all specific for cardiac muscle in that they have different chemical and immunochemical properties from the corresponding skeletal muscle proteins2–4. In addition, cardiac troponin I and cardiac troponin C have been shown to have different amino acid sequences from their skeletal muscle counterparts3,5.
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Department of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK
R. J. SOLARO, A. J. G. MOIR & S. V. PERRY
- R. J. SOLARO
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SOLARO, R., MOIR, A. & PERRY, S. Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart.Nature262, 615–617 (1976). https://doi.org/10.1038/262615a0
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