Developing a database of published reports of randomised clinical trials in pain research¹

Jadad, Alejandro R.^2,2; Carroll, Dawn; Moore, Andrew; McQuay, Henry^*

Oxford Pain Relief Unit, Nuffield Department of Anaesthetics, University of Oxford,Oxford,UK

^*Corresponding author: Dr Henry J. McQuay, Oxford Pain Relief Unit, The Churchill, Oxford Radcliffe Hospital, Oxford OX3 7LJ, UK. Tel.: (44) 1865 225774; Fax: (44) 1865 225775.

¹This article contains information presented as part of a thesis submitted by Dr Jadad for the degree of Doctor of Philosophy at the University of Oxford, Balliol College, Oxford, UK, 1994.

²Dr Jadad is currently a Post-Doctoral Fellow at the Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5.

Submitted October 30, 1995; accepted November 16, 1995.

Pain66(2):p 239-246, August 1996. |DOI:10.1016/0304-3959(96)03033-3

Abstract

A database of randomised clinical trials (RCTs) in pain research published from 1950 to 1990 was created following an extensive literature search. By applying a refined MEDLINE search strategy from 1966 to 1990 and by hand-searching more than 1 000 000 pages of a total of 40 biomedical journals published during the period 1950–1990, more than 8000 RCTs were identified. The RCTs were published in more than 800 journals and over 85% appeared between 1976 and 1990. If the trend of the last 15 years persists, a total of more than 15 000 RCTs will be published in pain relief by the year 2000. A detailed description of methods to ensure efficient use of resources during the identification, retrieval and management of the information in pain relief and other fields is given. Emphasis is made on the importance of refining MEDLINE search strategies, on the use of volunteers to hand-search journals and on careful monitoring of each of the steps of the process. The potential uses of the database to guide clinical and research decisions are discussed.