Movatterモバイル変換

[0]ホーム
URL:

Skip to main content

Advertisement

Springer Nature Link
Log in

Brain-Derived Neurotrophic Factor and Interleukin-6 Levels in the Serum and Cerebrospinal Fluid of Children with Viral Infection-Induced Encephalopathy

  • Original Paper
  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

We investigated changes in the brain-derived neurotrophic factor (BDNF) and interleukin (IL)-6 levels in pediatric patients with central nervous system (CNS) infections, particularly viral infection-induced encephalopathy. Over a 5-year study period, 24 children hospitalized with encephalopathy were grouped based on their acute encephalopathy type (the excitotoxicity, cytokine storm, and metabolic error types). Children without CNS infections served as controls. In serum and cerebrospinal fluid (CSF) samples, BDNF and IL-6 levels were increased in all encephalopathy groups, and significant increases were noted in the influenza-associated and cytokine storm encephalopathy groups. Children with sequelae showed higher BDNF and IL-6 levels than those without sequelae. In pediatric patients, changes in serum and CSF BDNF and IL-6 levels may serve as a prognostic index of CNS infections, particularly for the diagnosis of encephalopathy and differentiation of encephalopathy types.

This is a preview of subscription content,log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
¥17,985 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Japan)

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Explore related subjects

Discover the latest articles, news and stories from top researchers in related subjects.

References

  1. Barde YA, Edgar D, Thoenen H (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J 1:549–553

  2. Reichardt LF (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361:1545–1564

    Article PubMed CAS PubMed Central  Google Scholar 

  3. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS (2002) Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22:3251–3261

    PubMed CAS  Google Scholar 

  4. Azmitia EC (2001) Neuronal instability: implications for Rett’s syndrome. Brain Dev 23(Suppl 1):S1–S10

    Article PubMed  Google Scholar 

  5. Aronica E, Leenstra S, Jansen GH, van Veelen CW, Yankaya B, Troost D (2001) Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with epilepsy: colocalization with N-methyl-D acid receptor. Acta Neuropathol 101:383–392

    PubMed CAS  Google Scholar 

  6. Ma H, Yu B, Kong L, Zhang Y, Shi Y (2012) Neural stem cells over-expressing brain-derived neurotrophic factor (BDNF) stimulate synaptic protein expression and promote functional recovery following transplantation in rat model of traumatic brain injury. Neurochem Res 37:69–83

    Article PubMed CAS  Google Scholar 

  7. Qu WS, Wang YH, Wang JP, Tang YX, Zhang Q, Tian DS, Yu ZY, Xie MJ, Wang W (2010) Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia. Neurochem Res 35:1716–1724

    Article PubMed CAS  Google Scholar 

  8. Al-Ayadhi LY (2012) Relationship between sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism speControlum disorders. Neurochem Res 37:394–400

    Article PubMed CAS PubMed Central  Google Scholar 

  9. Simonato M, Tongiorgi E, Kokaia M (2006) Angels and demons: neurotrophic factors and epilepsy. Trends Pharmacol Sci 27:631–638

    Article PubMed CAS  Google Scholar 

  10. Zhang Y, Zhao J, Wang J, Jiao X (2010) Brain-derived neurotrophic factor inhibits phenylalanine-induced neuronal apoptosis by preventing RhoA pathway activation. Neurochem Res 35:480–486

    Article PubMed CAS  Google Scholar 

  11. Tokunaga Y, Kira R, Takahata Y, Gondo K, Mizuno Y, Aoki T, Hara T (2002) Neurotrophin-4 and glial cell line-derived neurotrophic factor in cerebral fluid from meningitis/encephalitis patients. Pediatr Neurol 27:102–105

    Article PubMed  Google Scholar 

  12. Chiaretti A, Antonelli A, Piastra M, Genovese O, Polidori G, Aloe L (2004) Expression of neurotrophic factors in CSF and plasma of children with viral and bacterial meningoencephalitis. Acta Paediatr 93:1178–1184

    Article PubMed CAS  Google Scholar 

  13. Mizuno Y, Takada H, Urakami K, Ihara K, Kira R, Suminoe A, Ohga S, Aoki T, Hara T (2000) Neurotrophin-3 levels in CSF from children with bacterial meningitis, viral meningitis, or encephalitis. J Child Neurol 15:19–21

    PubMed CAS  Google Scholar 

  14. Morichi S, Kashiwagi Y, Takekuma K, Hoshika A, Kawashima H (2013) Expressions of brain-derived neurotrophic factor (BDNF) in CSF and plasma of children with meningitis and encephalitis/encephalopathy. Int J Neurosci 123:17–23

    Article PubMed CAS  Google Scholar 

  15. Hsieh CC, Lu JH, Chen SJ, Lan CC, Chow WC, Tang RB (2009) Cerebrospinal fluid levels of interleukin-6 and interleukin-12 in children with meningitis. Childs Nerv Syst 25:461–465

    Article PubMed  Google Scholar 

  16. Mizuguchi M, Yamanouchi H, Ichiyama T, Shiomi M (2007) Acute encephalopathy associated with influenza and other viral infections. Acta Neurol Scand 115:45–56

    Article PubMed CAS  Google Scholar 

  17. Kawano G, Iwata O, Iwata S, Kawano K, Obu K, Kuki I, Rinka H, Shiomi M, Yamanouchi H, Kakuma T, Takashima S, Matsuishi T, Research Network for Acute Encephalopathy in Childhood (2011) Determinants of outcomes following acute child encephalopathy and encephalitis: pivotal effect of early and delayed cooling. Arch Dis Child 96:936–941

    Article PubMed CAS  Google Scholar 

  18. Kizawa-Ueda M, Ueda A, Kawamura N, Ishikawa T, Mutoh E, Fukuda Y, Shiroki R, Hoshinaga K, Ito S, Asakura K, Mutoh T (2011) Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis. Eur Neurol 653:138–143

    Article  Google Scholar 

  19. Stoica G, Lungu G, Kim HT, Wong PK (2008) Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathy. Brain Res 1208:204–216

    Article PubMed CAS  Google Scholar 

  20. Sellner J, Lenhard T, Haas J, Einsiedel R, Meyding-Lamadé U (2005) Differential mRNA expression of neurotrophic factors GDNF, BDNF, and NT-3 in experimental herpes simplex virus encephalitis. Brain Res Mol Brain Res 137:267–271

    Article PubMed CAS  Google Scholar 

  21. Yoshimura R, Umene-Nakano W, Hoshuyama T, Ikenouchi-Sugita A, Hori H, Katsuki A, Hayashi K, Atake K, Nakamura J (2010) Plasma levels of brain-derived neurotrophic factor and interleukin-6 in patients with dysthymic disorder: comparison with age- and sex-matched major depressed patients and healthy controls. Hum Psychopharmacol 25:566–569

    Article PubMed CAS  Google Scholar 

  22. Bibel M, Barde YA (2000) Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 14:2919–2937

    Article PubMed CAS  Google Scholar 

  23. Hashimoto K, Shimizu E, Iyo M (2004) Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev 45:104–114

    Article PubMed CAS  Google Scholar 

  24. Chao MV (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4:299–309 (Review)

    Article PubMed CAS  Google Scholar 

  25. Wang Y, Cao M, Liu A, Di W, Zhao F, Tian Y, Jia J (2013) Changes of inflammatory cytokines and neurotrophins emphasized their roles in hypoxic-ischemic brain damage. Int J Neurosci 123:191–195

    Article PubMed CAS  Google Scholar 

  26. Chiaretti A, Pulitanò S, Conti G, Barone G, Buonsenso D, Manni L, Capozzi D, Ria F, Riccardi R (2013) Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case–control study. Int J Infect Dis 17:e1186–e1193

    Article PubMed CAS  Google Scholar 

  27. Zhang R, Peng Z, Wang H, Xue F, Chen Y, Wang Y, Wang H, Tan Q (2014) Gastrodin ameliorates depressive-like behaviors and up-regulates the expression ofBDNF in the hippocampus and hippocampal-derived astrocyte of rats. Neurochem Res 39:172–179

    Article PubMed CAS  Google Scholar 

  28. Katsuragi S, Ikeda T, Ikenoue T (2011) A strategy to treat neonatal hypoxic encephalopathy using glial cell line-derived neurotrophic factor. No To Hattatsu 43:265–272

    PubMed  Google Scholar 

Download references

Acknowledgments

The authors wish to thank the physicians from the medical institutions that participated in the study.

Conflict of interest

The authors indicate no potential conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Shinichiro Morichi, Gaku Yamanaka, Yu Ishida, Shingo Oana, Yasuyo Kashiwagi & Hisashi Kawashima

Authors
  1. Shinichiro Morichi

    You can also search for this author inPubMed Google Scholar

  2. Gaku Yamanaka

    You can also search for this author inPubMed Google Scholar

  3. Yu Ishida

    You can also search for this author inPubMed Google Scholar

  4. Shingo Oana

    You can also search for this author inPubMed Google Scholar

  5. Yasuyo Kashiwagi

    You can also search for this author inPubMed Google Scholar

  6. Hisashi Kawashima

    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toShinichiro Morichi.

Rights and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Morichi, S., Yamanaka, G., Ishida, Y.et al. Brain-Derived Neurotrophic Factor and Interleukin-6 Levels in the Serum and Cerebrospinal Fluid of Children with Viral Infection-Induced Encephalopathy.Neurochem Res39, 2143–2149 (2014). https://doi.org/10.1007/s11064-014-1409-9

Download citation

Keywords

Access this article

Subscribe and save

Springer+ Basic
¥17,985 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Japan)

Instant access to the full article PDF.

Advertisement

[8]ページ先頭
©2009-2025 Movatter.jp