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Summary
Hospital charts from 59 patients with intracranial malignancy or epidural spinal cord compression were reviewed to establish the frequency of clinically important corticosteroid toxicities and to determine treatment or patient characteristics which were predictive for toxicity. Thirty patients (51%) developed at least one steroid toxicity and eleven (19%) required hospital admission for diagnosis and/or management of steroid-related complications. In this retrospective analysis the duration of steroid therapy and the total administered dose predicted for toxicity. Patients with toxicity also had a significant fall in the serum albumin level. Important corticosteroid toxicity occurs frequently in neuro-oncology patients. Further research should be directed at developing non-toxic alternatives to corticosteroids.
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Dukes MNG: Meyler's side effects of drugs. Excerpta Medica Amsterdam, Oxford, 1975, pp 812–840
Marshall LF, King J, Langfitt TW: The complications of high-dose corticosteroid therapy in neurosurgical patients: A prospective study. Ann Neurol 1:201–203, 1977
Renaudin J, Fewer D, Wilson CB, Boldrey EB, Calogero J, Enot KJ: Dose dependency of Decadron in patients with partially excised brain tumors. J Neurosurg 39:302–305, 1977
Greenberg HS, Jim JH, Posner JB: Epidural spinal cord compression from metastatic tumor: Results with a new treatment protocol. Ann Neurol 8:361–366, 1980
Slatkin NE, Posner JB: Management of spinal epidural metastases. Clin Neurosurg 3:698–716, 1982
Pezner RD, Lipsett JA. Peptic ulcer disease and other complications in patients receiving dexamethasone palliation for brain metastasis. West J Med 137:375–378, 1982
Martenson JA, Evans RG, Lie MR, Ilstrup DM, Dinapoli RP, Ebersold MJ, Earle JD: Treatment outcome and complications in patients treated for malignant epidural spinal cord compression (SCC). J Neurooncol, 3:77–84, 1985
Warshaw AL, Welch JP, Ottinger LW: Acute perforation of the colon associated with chronic corticosteroid therapy. Am J Surg 131:442–446, 1976
Butcher DL, Saha SA: Epidural lipomatosis: A complication of corticosteroid therapy. Ann Intern Med 90:60, 1979
The Boston Collaborative Drug Surveillance Program. Acute adverse reactions to prednisone in relation to dosage. Clin Pharmacol Ther 13:694–698, 1972
Lewis GP, Jusko WJ, Burke CW, Graves L: Prednisone side-effects and serum protein levels. Lancet 2:778–780, 1971
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The Johns Hopkins Oncology Center, The Johns Hopkins Hospital, Baltimore, Maryland, USA
David E. Weissman, Denise Dufer, Victor Vogel & Martin D. Abeloff
- David E. Weissman
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- Denise Dufer
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- Victor Vogel
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- Martin D. Abeloff
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Weissman, D.E., Dufer, D., Vogel, V.et al. Corticosteroid toxicity in neuro-oncology patients.J Neuro-Oncol5, 125–128 (1987). https://doi.org/10.1007/BF02571300
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