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Structure and expression of the gene encoding CD8α chain (Leu-2/T8)

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References

  • Anderson, S. J., Chou, H. S., and Loh, D.: A conserved sequence in the T-cell receptor β-chain promoter region.Proc Natl Acad Sci USA 85: 3551–3554, 1988

    Article PubMed CAS  Google Scholar 

  • DiSanto, J. P., Knowles, R. W., and Flomenberg, N.: The human Lyt-3 molecule requires CD8 for cell surface expression.EMBO J 7: 3464–3470, 1988

    Google Scholar 

  • Fujimoto, J., Levy, S., and Levy, R.: Spontaneous release of the Leu-2 (T8) molecule from human T cells.J Exp Med 159: 752–766, 1983

    Article  Google Scholar 

  • Fujimoto, J., Stewart, S., and Levy, R.: Immunochemical analysis of the released Leu-2 (T8) molecules.J Exp Med 160: 116–124, 1984

    Article PubMed CAS  Google Scholar 

  • Giblin, P., Ledbetter, J. A., and Kavathas, P.: A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.Proc Natl Acad Sci USA 86: 998–1002, 1989

    Article PubMed CAS  Google Scholar 

  • Johnson, P.: A human homolog of the mouse CD8 molecule, Lyt-3: genomic sequence and expression.Immunogenetics 26: 174–177, 1987

    Article PubMed CAS  Google Scholar 

  • Johnson, P. and Williams, A. F.: Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigen.Nature 323: 74–76, 1986

    Article PubMed CAS  Google Scholar 

  • Kavathas, P., Sukhatme, V. P., Herzenberg, L. A., and Parnes, J. R.: Isolation of the gene encoding the hunan T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction.Proc Natl Acad Sci USA 81: 7688–7692, 1984

    Article PubMed CAS  Google Scholar 

  • Lanier, L. L., Le, A. M., Civin, C. I., Loken, M. R., and Phillips, J. H.: The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.J Immunol 136: 4480–4486, 1986

    PubMed CAS  Google Scholar 

  • Ledbetter, J. A., Seaman, W. E., Tsu, T. T., and Herzenberg, L. A. Lyt-2 and Lyt-3 antigens are on two different peptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity.J Exp Med 153: 1503–1516, 1981

    Article PubMed CAS  Google Scholar 

  • Liaw, C, W., Zamoyska, R., and Parnes, J. R.: Structure, sequence, and polymorphism of the Lyt-2T cell differentiation antigen gene.J Immunol 137: 1037–1043, 1986

    PubMed CAS  Google Scholar 

  • Littman, D. R., Thomas, Y., Maddon, P. J., Chess, L., and Axel, R.: The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.Cell 40: 237–246, 1985

    Article PubMed CAS  Google Scholar 

  • Nakauchi, H., Nolan, G. P., Hsu, C., Huang, H. S., Kavathas, P., and Herzenberg, L. A.: Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology ot its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.Proc Natl Acad Sci USA 82: 5126–5130, 1985

    Article PubMed CAS  Google Scholar 

  • Nakauchi, H., Shinjai, Y., and Okumura, K.: Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions.Proc Natl Acad Sci USA 84: 4210–4214, 1987a

    Article PubMed CAS  Google Scholar 

  • Nakauchi, H., Tagawa, M., Nolan, G. P., and Herzenberg, L. A.: Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2.Nucleic Acids Res 15: 4337–4347, 1987b

    PubMed CAS  Google Scholar 

  • Nakayama, K.-I. and Nakauchi, H.: An improved method to make sequential deletion mutants for DNA sequencing.Trends Genet, in press, 1989

  • Nakayama, K.-I., Shinkai, Y.-I., Okumura, K., and Nakauchi, H.: Isolation and characterization of the mouse CD8 β-chain (Ly-3) genes: absence of an intervening sequence between V-and J-like gene segments.J Immunol 142: 2540–2546, 1989

    PubMed CAS  Google Scholar 

  • Norment, A. M. and Littman, D. R.: A second subunit of CD8 is expressed in human T cells.EMBO J 7: 3433–3439, 1988a

    PubMed CAS  Google Scholar 

  • Norment, A. M., Salter, R. D., Parham, P., Engelhard, V. E., and Littman, D. R.: Cell-cell adhesion mediated by CD8 and MHC class I molecules.Nature 336: 79–81, 1988b

    Article PubMed CAS  Google Scholar 

  • Norment, A. M., Lonberg, N., Lacy, E., and Littman, D. R.: Alternatively spliced mRNA encodes a secreted form of human CD8α: characterization of the human CD8α gene.J Immunol 142: 3312–3319, 1989

    PubMed CAS  Google Scholar 

  • Panaccio, M., Gillespie, M. T., Walker, I. D., Kirszbaum, L., Sharpe, J. A., Tobias, G. H., McKenzie, I. F. G., and Deacon, N. J.: Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8).Proc Natl Acad Sci USA 84: 6874–6878, 1987

    Article PubMed CAS  Google Scholar 

  • Rosenstein, Y., Ratnofsky, S., Burakoff, S. J., and Herrmann, S. H.: Direct evidence for binding CD8 to HLA class I antigens.J Exp Med 169: 149–160, 1989

    Article PubMed CAS  Google Scholar 

  • Shiue, L., Gorman, S. D., and Parnes, J. R.: a second chain of human CD8 is expressed on peripheral blood lymphocytes.J Exp Med 168: 1993–2005, 1988

    Article PubMed CAS  Google Scholar 

  • Smale, S. T. and Baltimore, D.: The “initiator” as a transcription control element.Cell 57: 103–113, 1989

    Article PubMed CAS  Google Scholar 

  • Sukhatme, V. P., Sizer, K. C., Vollmer, A. C., Hunkapiller, T., and Parnes, J. R.: The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.Cell 40: 591–597, 1985

    Article PubMed CAS  Google Scholar 

  • Swain, S. L.: T cell subsets and recognition of MHC class.Immunol Rev 74: 129–142, 1983

    Article PubMed CAS  Google Scholar 

  • Tagawa, M., Nakauchi, H., Herzenberg, L. A., and Nolan, G. P.: Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and posttranscriptional regulation.Proc Natl Acad Sci USA 83: 3422–3426, 1986

    Article PubMed CAS  Google Scholar 

  • Zamoyska, R., Vollmer, A. C., Sizer, K. C., Liaw, C. W., and Parnes, J. R.: Two Lyt-2 peptides arise from a single gene by alternative splicing patterns of mRNA.Cell 43: 153–163, 1985

    Article PubMed CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Molecular Regulation of Aging, Frontier Research Program, The Institute of Physical and Chemical Research (RIKEN), 3-1-1 Koyadai, Tsukuba, 305, Ibaraki, Japan

    Kei-ichi Nakayama, Satoki Tokito & Hiromitsu Nakauchi

  2. Department of Immunology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113, Tokyo, Japan

    Kei-ichi Nakayama & Ko Okumura

Authors
  1. Kei-ichi Nakayama
  2. Satoki Tokito
  3. Ko Okumura
  4. Hiromitsu Nakauchi

Additional information

The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number M27161.

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Nakayama, Ki., Tokito, S., Okumura, K.et al. Structure and expression of the gene encoding CD8α chain (Leu-2/T8).Immunogenetics30, 393–397 (1989). https://doi.org/10.1007/BF02425282

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