Movatterモバイル変換


[0]ホーム

URL:


Skip to main content
Springer Nature Link
Log in

Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction

  • Published:
Naunyn-Schmiedeberg's Archives of Pharmacology Aims and scope Submit manuscript

Summary

The effects of mianserin, a tetracyclic antidepressant, and adinazolam, a new triazolobenzodiazepine which has antidepressant activity, on intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation were studied in the dog heart after myocardial infarction and compared to the effects of amitriptyline, a standard tricyclic antidepressant.

Amitriptyline at a dose of 1 mg/kg significantly slowed ventricular conduction in a frequency-dependent manner and at doses of 2 and 3 mg/kg significantly slowed ventricular conduction in infarcted ventricular myocardium. Amitriptyline also significantly slowed ventricular conduction in normal myocardium. Amitriptyline increased the incidence of ventricular arrhythmias induced by the programmed ventricular stimulation and prolonged the intraventricular delayed conduction resulting in re-entrant ventricular arrhythmia.

On the other hand, mianserin and adinazolam at doses of 1–3 mg/kg had no significant effects on intraventricular conduction in infarcted and normal myocardium and on the incidence of arrhythmias induced by programmed ventricular stimulation. From these results, we can expect that mianserin and adinazolam may have a much lower cardiac toxicity than amitriptyline.

This is a preview of subscription content,log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
¥17,985 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Japan)

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Amsterdam JD, Kaplan M, Potter L, Bloom L, Rickels K (1986) Adinazolam, a new triazolobenzodiazepine, and imipramine in the treatment of major depressive disorder. Psychopharmacol 88:484–488

    Google Scholar 

  • Barth N, Manus M, E (1975) Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart. Naunyn-Schmiedeberg's Arch Pharmacol 288:215–231

    Google Scholar 

  • Barth N, Muscholl E (1974) The effects of the tricyclic antidepressants desipramine, doxepine and iprindole on the isolated perfused rabbit heart. Naunyn-Schmiedeberg's Arch Pharmacol 284:215–232

    Google Scholar 

  • Baum T, Shropshire AT, Rowles G, Gluckman MI (1971) Antidepressants and cardiac conduction: iprindole and imipramine. Eur J Pharmacol 13:287–291

    Google Scholar 

  • Baumann PA, Maitre L (1977) Blockade of presynaptic α-receptors and of amine uptake in the rat brain by the antidepressant mianserine. Naunyn-Schmiedeberg's Arch Pharmacol 300:31–37

    Google Scholar 

  • Burgess CD, Turner P (1978) Cardiovascular responses to mianserin hydrochloride: A comparison with tricyclic antidepressant drugs. Br J Clin Pharmacol 5 (Suppl 1):21S–28S

    Google Scholar 

  • Coppen A, Gupta R, Montgomery S, Ghose K, Bailey J, Burns B, De Ridder JJ (1976) Mianserin hydrochloride: A novel antidepressant. Br J Psychiat 129:342–345

    Google Scholar 

  • Coppen A, Kopera H (1978) Workshop on the clinical pharmacology and efficacy of mianserin. Br J Clin Pharmacol 5 (Suppl 1):91S–99S

    Google Scholar 

  • Coull DC, Crooks J, Dingwall-Fordyce I, Scott AM, Weir RD (1970) A method of comonitoring drugs for adverse reaction. II. Amitriptyline and cardiac disease. Eur J Clin Pharmacol 3:51–55

    Google Scholar 

  • Edwards JG, Goldie A (1983) Mianserin, maprotiline and intracardiac conduction. Br J Clin Pharmacol 15 (Suppl 2):249S–254S

    Google Scholar 

  • El-Sherif N, Scherlag BJ, Lazzara R, Hope RR (1977a) Re-entrant ventricular arrhythmias in the late myocardial infarction period. 1. Conduction characteristics in the infarction zone. Circulation 55:686–702

    Google Scholar 

  • El-Sherif N, Hope RR, Scherlag BJ, Lazzara R (1977b) Re-entrant ventricular arrhythmias in the late myocardial infarction periods. 2. Patterns of initiation and termination of re-entry. Circulation 55:702–719

    Google Scholar 

  • Feighner JP (1986) A review of controlled studies of adinazolam mesylate in patients with major depressive disorder. Psychopharmacol Bull 22:186–191

    Google Scholar 

  • Ghose K, Coppen A, Turner P (1976) Autonomic actions and interactions of mianserin hydrochloride and amitriptyline in patients with depressive illness. Psychopharmacol 49:201–204

    Google Scholar 

  • Harper B, Hughes IE (1977) A comparison in rabbit isolated hearts of the dysrhythmogenic potential of amitriptyline, maprotiline and mianserin in relation to their ability to block noradrenaline uptake. Br J Pharmacol 59:651–660

    Google Scholar 

  • Harris AS (1950) Delayed development of ventricular ectopic rhythm following experimental coronary occlusion. Circulation 1:1318–1329

    Google Scholar 

  • Hopman H (1980) Mianserin, out-patients with depressive illness, in dosage up to 130 mg daily. Curr Med Res Opin 6 (Suppl 7) 107–114

    Google Scholar 

  • Junien JL, Lakatos C, Padioleau F (1976) Studies of the effects of imipramine on cardiac conduction in anesthetized dogs by His bundle electrogram recording. J Cardiovasc Pharmacol 7:133–138

    Google Scholar 

  • Kopera RA (1980) Cardiac effects of mianserin: results of clinical pharmacological investigation. Curr Med Res Opin 6:36–42

    Google Scholar 

  • Lahti RA, Pyke RE, Sethy VH (1984) Adinazolam, a triazolobenzodiazepine antidepressant. Preclinical and clinical data. In: IUPHAR 9th International Congress of Pharmacology. The Macmillan Press, London, abstract 1983P

    Google Scholar 

  • Marshall JB, Forker AD (1982) Cardiovascular effects of tricyclic antidepressant drugs: Therapeutic usage, overdose, and management of complications. AM Heart J 103:401–414

    Google Scholar 

  • Matsuo S (1967) Comparative effects of imipramine and propranolol on the transmembrane potentials of the isolated rabbit's atria. Jap J Pharmacol 17:279–286

    Google Scholar 

  • Moir OC, Cornwell WB, Dingwall-Fordyce I, Crooks J, O'Malley K, Turnbull MJ (1972) Cardiotoxicity of amitriptyline. The Lancet 2:561–564

    Google Scholar 

  • Montgomery S (1983) Advances with antidepressants: clinical experiences with mianserin. Act Psychiat Scand 67 (Suppl. 305):90–94

    Google Scholar 

  • Nattel S (1985) Frequency-dependent effects of amitriptyline on ventricular conduction and cardiac rhythm in dogs. Circulation 72:1423–1428

    Google Scholar 

  • Nishimoto M, Hashimoto H, Ozaki T, Nagashima S, Nakashima M (1989) Comparative effects of antidepressants, amitriptyline, mianserin and adinazolam, on hemodynamics and ECG in myocardial infarcted dogs. Arch Int Pharmacodyn Ther 299:98–109

    Google Scholar 

  • Pyke RE, Cohn JB, Feighner JP, Smith WT (1983) Open-label studies of adinazolam in severe depression. Psychopharmacol Bull 19:96–98

    Google Scholar 

  • Turmel A, De Montigny C (1984) Sensitization of rat forebrain neurons to serotonin by adinazolam, an antidepressant triazolobenzodiazepine. Eur J Pharmacol 99:241–244

    Google Scholar 

  • Vohra J, Burrows G, Hunt D, Sloman G (1975) The effects of toxic and therapeutic doses of tricyclic antidepressant drugs on intracardiac conduction. Eur J Cardiol 3:219–227

    Google Scholar 

  • Wester HA, Siegers CP (1980) Cardiovascular effects of mianserin and amitriptyline in healthy volunteers. Int J Clin Pharmac Biopharmacy 18:513–517

    Google Scholar 

  • Wishnie HA, Hackett TP, Cassem NH (1970) Psychological hazards of convalescence following myocardial infarction. JAMA 215:1292–1298

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Hamamatsu University School of Medicine, 3600, Handa-cho, 431-31, Hamamatsu, Japan

    M. Nishimoto, H. Hashimoto, T. Ozaki, S. Nagashima & M. Nakashima

Authors
  1. M. Nishimoto

    You can also search for this author inPubMed Google Scholar

  2. H. Hashimoto

    You can also search for this author inPubMed Google Scholar

  3. T. Ozaki

    You can also search for this author inPubMed Google Scholar

  4. S. Nagashima

    You can also search for this author inPubMed Google Scholar

  5. M. Nakashima

    You can also search for this author inPubMed Google Scholar

Additional information

Send offprint requests to M. Nishimoto at the above address

Rights and permissions

About this article

Cite this article

Nishimoto, M., Hashimoto, H., Ozaki, T.et al. Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction.Naunyn-Schmiedeberg's Arch Pharmacol341, 240–245 (1990). https://doi.org/10.1007/BF00169737

Download citation

Key words

Access this article

Subscribe and save

Springer+ Basic
¥17,985 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Japan)

Instant access to the full article PDF.

Advertisement


[8]ページ先頭

©2009-2025 Movatter.jp