Part of the book series:Advances in Experimental Medicine and Biology ((AEMB,volume 1074))
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Abstract
Within the mammalian retina, both Müller glia and astrocytes display reactivity in response to many forms of retinal injury and disease in a process termed gliosis. Reactive gliosis is a complex process that is considered to represent a cellular response to protect the retina from further damage and to promote its repair following pathological insult. It includes morphological, biochemical and physiological changes, which may vary depending on the type and degree of the initial injury. Not only does gliosis have numerous triggers, but also there is a great degree of heterogeneity in the glial response, creating multiple levels of complexity. For these reasons, understanding the process of glial scar formation and how this process differs in different pathological conditions and finding strategies to circumvent these barriers represent major challenges to the advancement of many ocular therapies.
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Authors and Affiliations
Department of Genetics, University College London Institute of Ophthalmology, London, UK
Anna B. Graca & Rachael A. Pearson
Roche, Stem Cell Platform, Chemical Biology Roche Pharma Research and Early Development, Basel, Switzerland
Claire Hippert
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Correspondence toAnna B. Graca orRachael A. Pearson.
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Editors and Affiliations
Department of Ophthalmology, University of Florida, Gainesville, Florida, USA
John D. Ash
Ophthalmology and Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Robert E. Anderson
School of Medicine Beckman Vision Center, University of California San Francisco, San Francisco, California, USA
Matthew M. LaVail
Departments of Ophthalmology and Cell Biology, Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA
Catherine Bowes Rickman
Division of Ophthalmology, Case Western Reserve University, Cleveland, Ohio, USA
Joe G. Hollyfield
Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland
Christian Grimm
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Graca, A.B., Hippert, C., Pearson, R.A. (2018). Müller Glia Reactivity and Development of Gliosis in Response to Pathological Conditions. In: Ash, J., Anderson, R., LaVail, M., Bowes Rickman, C., Hollyfield, J., Grimm, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 1074. Springer, Cham. https://doi.org/10.1007/978-3-319-75402-4_37
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