- Vicky Y. Wang16,
- Alexander J. Wilson16,17,
- Gregory B. Sands16,17,
- Alistair A. Young16,18,
- Ian J. LeGrice16,17 &
- …
- Martyn P. Nash16,19
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Abstract
Changes in heart geometry and microstructural remodelling of myocardium are pathological processes that occur in heart failure (HF). The combination of effects often leads to compromised mechanical function of the left ventricle (LV). We have developed an image-driven constitutive modelling framework, which integrates subject-specific geometric data and microstructural organisation of the myocardial tissue, in order to investigate the mechanisms of heart function in health and disease. In this study, we investigated the effect of myocardial microstructural remodelling on passive mechanical function of the LV during the progression of hypertension-induced HF. We constructed finite element models of the LV using geometric data derived fromin vivo magnetic resonance images of healthy and failing rat hearts at both 14-months and 24-months of age. By incorporating subject-specific LV geometries and parameters that directly reflect the tissue microstructure, we demonstrated that a single set of fitted constitutive parameters could reproduce the observed LV chamber compliance curves in all four cases (healthy and diseased hearts at 14-months and 24-months). This study highlights the important role that remodelling of myocardial microstructure plays in the mechanics of the failing heart.
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Authors and Affiliations
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
Vicky Y. Wang, Alexander J. Wilson, Gregory B. Sands, Alistair A. Young, Ian J. LeGrice & Martyn P. Nash
Department of Physiology, University of Auckland, Auckland, New Zealand
Alexander J. Wilson, Gregory B. Sands & Ian J. LeGrice
Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand
Alistair A. Young
Department of Engineering Science, University of Auckland, Auckland, New Zealand
Martyn P. Nash
- Vicky Y. Wang
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Correspondence toVicky Y. Wang.
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Eindhoven University of Technology, Eindhoven, The Netherlands
Hans van Assen
Eindhoven University of Technology, Eindhoven, The Netherlands
Peter Bovendeerd
Maastricht University, Maastricht, The Netherlands
Tammo Delhaas
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Wang, V.Y., Wilson, A.J., Sands, G.B., Young, A.A., LeGrice, I.J., Nash, M.P. (2015). Microstructural Remodelling and Mechanics of Hypertensive Heart Disease. In: van Assen, H., Bovendeerd, P., Delhaas, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2015. Lecture Notes in Computer Science(), vol 9126. Springer, Cham. https://doi.org/10.1007/978-3-319-20309-6_44
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