- Micah A. Chrenek7,
- Jana T. Sellers7,
- Eric C. Lawson7,8,
- Priscila P. Cunha7,
- Jessica L. Johnson7,
- Preston E. Girardot7,
- Cristina Kendall7,
- Moon K. Han7,8,
- Adam Hanif7,8,
- Vincent T. Ciavatta7,8,
- Marissa A. Gogniat7,8,
- John M. Nickerson7,
- Machelle T. Pardue7,8 &
- …
- Jeffrey H. Boatright PhD7,8
Part of the book series:Advances in Experimental Medicine and Biology ((AEMB,volume 854))
5383Accesses
Abstract
To compare patterns of gene expression following preconditioning cyclic light rearing versus preconditioning aerobic exercise. BALB/C mice were preconditioned either by rearing in 800 lx 12:12 h cyclic light for 8 days or by running on treadmills for 9 days, exposed to toxic levels of light to cause light-induced retinal degeneration (LIRD), then sacrificed and retinal tissue harvested. Subsets of mice were maintained for an additional 2 weeks and for assessment of retinal function by electroretinogram (ERG). Both preconditioning protocols partially but significantly preserved retinal function and morphology and induced similar leukemia inhibitory factor (LIF) gene expression pattern. The data demonstrate that exercise preconditioning and cyclic light preconditioning protect photoreceptors against LIRD and evoke a similar pattern of retinal LIF gene expression. It may be that similar stress response pathways mediate the protection provided by the two preconditioning modalities.
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Acknowledgments
Supported by NIH P30 EY006360, NIH R01 EY014026 and a grant from the Abraham J. & Phyllis Katz Foundation (to J.H.B.), Rehabilitation Research and Development Service Veterans Affairs Research Career Scientist Award (to M.T.P.), Atlanta VA Center of Excellence in Vision and Neurocognitive Rehabilitation, and Departmental Award from Research to Prevent Blindness.
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Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA
Micah A. Chrenek, Jana T. Sellers, Eric C. Lawson, Priscila P. Cunha, Jessica L. Johnson, Preston E. Girardot, Cristina Kendall, Moon K. Han, Adam Hanif, Vincent T. Ciavatta, Marissa A. Gogniat, John M. Nickerson, Machelle T. Pardue & Jeffrey H. Boatright PhD
Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA
Eric C. Lawson, Moon K. Han, Adam Hanif, Vincent T. Ciavatta, Marissa A. Gogniat, Machelle T. Pardue & Jeffrey H. Boatright PhD
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Editors and Affiliations
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Catherine Bowes Rickman
Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA
Matthew M. LaVail
Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA
Robert E. Anderson
University Hospital Zurich, Zurich, Switzerland
Christian Grimm
Case Western Reserve University Cleveland Clinic Lerner College of Med, Cleveland, Ohio, USA
Joe Hollyfield
Univ of Florida Dept of Ophthalmology/Arb R112, Gainesville, Florida, USA
John Ash
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Chrenek, M.et al. (2016). Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_59
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