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Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns

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Abstract

To compare patterns of gene expression following preconditioning cyclic light rearing versus preconditioning aerobic exercise. BALB/C mice were preconditioned either by rearing in 800 lx 12:12 h cyclic light for 8 days or by running on treadmills for 9 days, exposed to toxic levels of light to cause light-induced retinal degeneration (LIRD), then sacrificed and retinal tissue harvested. Subsets of mice were maintained for an additional 2 weeks and for assessment of retinal function by electroretinogram (ERG). Both preconditioning protocols partially but significantly preserved retinal function and morphology and induced similar leukemia inhibitory factor (LIF) gene expression pattern. The data demonstrate that exercise preconditioning and cyclic light preconditioning protect photoreceptors against LIRD and evoke a similar pattern of retinal LIF gene expression. It may be that similar stress response pathways mediate the protection provided by the two preconditioning modalities.

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Acknowledgments

Supported by NIH P30 EY006360, NIH R01 EY014026 and a grant from the Abraham J. & Phyllis Katz Foundation (to J.H.B.), Rehabilitation Research and Development Service Veterans Affairs Research Career Scientist Award (to M.T.P.), Atlanta VA Center of Excellence in Vision and Neurocognitive Rehabilitation, and Departmental Award from Research to Prevent Blindness.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA

    Micah A. Chrenek, Jana T. Sellers, Eric C. Lawson, Priscila P. Cunha, Jessica L. Johnson, Preston E. Girardot, Cristina Kendall, Moon K. Han, Adam Hanif, Vincent T. Ciavatta, Marissa A. Gogniat, John M. Nickerson, Machelle T. Pardue & Jeffrey H. Boatright PhD

  2. Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA

    Eric C. Lawson, Moon K. Han, Adam Hanif, Vincent T. Ciavatta, Marissa A. Gogniat, Machelle T. Pardue & Jeffrey H. Boatright PhD

Authors
  1. Micah A. Chrenek

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  2. Jana T. Sellers

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  3. Eric C. Lawson

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  4. Priscila P. Cunha

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  5. Jessica L. Johnson

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  6. Preston E. Girardot

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  7. Cristina Kendall

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  8. Moon K. Han

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  9. Adam Hanif

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  10. Vincent T. Ciavatta

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  11. Marissa A. Gogniat

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  12. John M. Nickerson

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  13. Machelle T. Pardue

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  14. Jeffrey H. Boatright PhD

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Corresponding author

Correspondence toJeffrey H. Boatright PhD.

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

  2. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  3. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  4. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  5. Case Western Reserve University Cleveland Clinic Lerner College of Med, Cleveland, Ohio, USA

    Joe Hollyfield

  6. Univ of Florida Dept of Ophthalmology/Arb R112, Gainesville, Florida, USA

    John Ash

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© 2016 Springer International Publishing Switzerland

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Cite this paper

Chrenek, M.et al. (2016). Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_59

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JPY 25167
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Softcover Book
JPY 31459
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