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Evaluating Intensity Concentrations During the Spatial Normalization of Functional Images for Parkinson’s Disease

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Abstract

The aim of this study is to assess the changes in imaging of dopamine transporters using [123]I-FP-CIT SPECT when applying a deformation of the striatum using a linear and/or a non-linear registration to a reference template. For that, the deformation has been indirectly measured studying the changes in the intensity values in two different scenarios when, during the interpolation stage, the amount or the concentrations of intensity values are preserved. As showed by our results, the degree of deformation is greater in images from patients with Parkinson’s Disease than in healthy control subjects.

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Acknowledgments

This work was supported by the MCIN/AEI/10.13039/501100011033/ and FEDER “Una manera de hacer Europa” under the RTI2018-098913-B100 project; by the Consejería de Economía, Innovación, Ciencia y Empleo (Junta de Andalucía) and FEDER under CV20-45250, A-TIC-080-UGR18, B-TIC-586-UGR20 and P20-00525 projects; and by the Ministerio de Universidades under the FPU18/04902 grant given to C. Jimenez-Mesa and the Margarita-Salas grant to J.E. Arco.

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Authors and Affiliations

  1. Department of Signal Theory, Telematics and Communications, University of Granada, Periodista Daniel Saucedo Aranda, 18071, Granada, Spain

    Diego Castillo-Barnes, C. Jimenez-Mesa, J. Ramirez, J. M. Górriz & D. Salas-Gonzalez

  2. Department of Communications Engineering, University of Malaga, Blvr. Louis Pasteur 35, 29004, Malaga, Spain

    Juan E. Arco

Authors
  1. Diego Castillo-Barnes

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  2. Juan E. Arco

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  3. C. Jimenez-Mesa

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  4. J. Ramirez

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  5. J. M. Górriz

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  6. D. Salas-Gonzalez

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Corresponding author

Correspondence toDiego Castillo-Barnes.

Editor information

Editors and Affiliations

  1. Universidad Politécnica de Cartagena, Cartagena, Spain

    José Manuel Ferrández Vicente

  2. Universidad Nacional de Educación a Distancia, Madrid, Spain

    José Ramón Álvarez-Sánchez

  3. Universidad Nacional de Educación a Distancia, Madrid, Spain

    Félix de la Paz López

  4. Ohio State University, Columbus, OH, USA

    Hojjat Adeli

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Castillo-Barnes, D., Arco, J.E., Jimenez-Mesa, C., Ramirez, J., Górriz, J.M., Salas-Gonzalez, D. (2022). Evaluating Intensity Concentrations During the Spatial Normalization of Functional Images for Parkinson’s Disease. In: Ferrández Vicente, J.M., Álvarez-Sánchez, J.R., de la Paz López, F., Adeli, H. (eds) Artificial Intelligence in Neuroscience: Affective Analysis and Health Applications. IWINAC 2022. Lecture Notes in Computer Science, vol 13258. Springer, Cham. https://doi.org/10.1007/978-3-031-06242-1_18

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