Part of the book series:Methods in Molecular Biology™ ((MIMB,volume 538))
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Summary
Hematopoietic stem cells are at the foundation of the blood system. Their study is not only relevant to the understanding of the basic cellular mechanisms of self-renewal, lineage commitment, and differentiation, but they have also been the target of intense clinical research into the causes of leukemia and the exploitation of these cells for cell replacement therapies. The basic mechanisms of hematopoietic stem cell regulation become evident in the way these cells are first generated and expanded during development. Isolating and analyzing hematopoietic stem cells from the embryo is therefore of direct clinical importance.
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Acknowledgements
We acknowledge the technical assistance of Fredrik Wallberg, Kam-Wing Ling, and Catherine Robin. This work was supported by Wellcome International Prize Travelling Fellowship GR063331MA (K.O.), Netherlands VICI ZonMW 916.36.6001 (E.D.), and Netherlands BSIK 03038 SCDD Award (E.D.). K.O. is currently supported by a Kay Kendall Leukaemia Fund Intermediate Fellowship (KKL276).
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Authors and Affiliations
Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK
Katrin Ottersbach
- Katrin Ottersbach
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- Elaine Dzierzak
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Correspondence toKatrin Ottersbach.
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Editors and Affiliations
King's College London, The University of London, London, UK
Chi Wai Eric So (Professor and Chair in Leukaemia Biology) (Professor and Chair in Leukaemia Biology)
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© 2009 Humana Press, a part of Springer Science+Business Media, LLC
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Ottersbach, K., Dzierzak, E. (2009). Analysis of the Mouse Placenta as a Hematopoietic Stem Cell Niche. In: Eric So, C.W. (eds) Leukemia. Methods in Molecular Biology™, vol 538. Humana Press. https://doi.org/10.1007/978-1-59745-418-6_17
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