Movatterモバイル変換

[0]ホーム
URL:

Skip to main content
Springer Nature Link
Log in

Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel,Piper betle

  • Note
  • Published:
Journal of Natural Medicines Aims and scope Submit manuscript

Abstract

The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves ofPiper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.

This is a preview of subscription content,log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
¥17,985 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Japan)

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Massey V, Brumby PE, Komai H, Palmer G (1969) Studies on milk xanthine oxidase. J Biol Chem 244:1682–1691

    Google Scholar 

  2. Yasuda T, Yoshida T, Goda AE, Horinaka M, Yano K, Shiraishi T, Wakada M, Mizutani Y, Miki T, Sakai T (2008) Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with tumor necrosis factor-related apoptosis-inducing ligand. Mol Cancer Res 6:1852–1860

    Article PubMed CAS  Google Scholar 

  3. Acker S, Berg D, Tromp M, Griffioen D, Bennekom W, Vijgh W, Bast A (1996) Structural aspects of antioxidant activity of flavonoids. Free Rad Biol Med 20:331–342

    Article PubMed  Google Scholar 

  4. Rice-Evans C, Miller N, Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad Biol Med 20:933–956

    Article PubMed CAS  Google Scholar 

  5. Nagao A, Seki M, Kobayashi H (1999) Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem 63:1787–1790

    Article PubMed CAS  Google Scholar 

  6. Nguyen M, Awale S, Tezuka Y, Ueda J, Tran Q, Kadota S (2006) Xanthine oxidase inhibitors from the flowers ofChrysanthemum sinense. Planta Med 72:46–51

    Article PubMed CAS  Google Scholar 

  7. Lei D, Chan C, Wang Y, Wang T, Lin B, Huang C, Lee J, Chen H, Jeng J, Chang M (2003) Antioxidative and antiplatelet effects of aqueous inflorescencePiper betle extract. J Agric Food Chem 51:2083–2088

    Article PubMed CAS  Google Scholar 

  8. Gülçín Í (2005) The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds. Int J Food Sci Nutr 56:491–499

    Article PubMed  Google Scholar 

  9. Rathee J, Patro B, Mula S, Gamre S, Chattopadhyay S (2006) Antioxidant activity ofPiper betel leaf extract and its constituents. J Agric Food Chem 54:9046–9054

    Article PubMed CAS  Google Scholar 

  10. Singh R, Rao H (2008) In vitro antioxidant activity ofPiper nigrum Linn. Phcog Mag 4:115–120

    Google Scholar 

  11. Chang M, Uang B, Tsai C, Wu H, Lin B, Lee C, Chen Y, Chang C, Tsai Y, Kao C, Jeng J (2007) Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization. Br J Pharm 152:73–82

    Article CAS  Google Scholar 

  12. Ghosh K, Bhattacharya T (2005) Chemical constituents ofPiper betle Linn. (Piperaceae) roots. Molecules 10:798–802

    Article PubMed CAS  Google Scholar 

  13. Chang W, Lee Y, Lu F, Chiang H (1993) Inhibitory effect of flavonoids on xanthine oxidase. Anticancer Res 13:2165–2170

    PubMed CAS  Google Scholar 

Download references

Acknowledgments

The authors are grateful to Prof. Ih-Sheng Chen at Kaohsiung Medical University in Taiwan for a valuable discussion. This work was financially supported by the “Antiaging Center Project” for Private Universities from Ministry of Education, Culture, Sports, Science and Technology, 2008–2012.

Author information

Authors and Affiliations

  1. School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan

    Kazuya Murata, Noriko Hirata, Kensuke Namba & Hideaki Matsuda

  2. Research Institute of Oriental Medicine, Kinki University, 377-2 Ohno-higashi, Osakasayama, Osaka, 589-8511, Japan

    Kikuyo Nakao, Kenzo Moriyama & Takahiro Shintani

  3. Nichinichi Pharmaceutical Co., Ltd., 239-1 Tominaga, Iga, Mie, 518-1417, Japan

    Takao Nomi & Yoshihisa Kitamura

  4. Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, 502-8585, Japan

    Munekazu Iinuma

Authors
  1. Kazuya Murata

    You can also search for this author inPubMed Google Scholar

  2. Kikuyo Nakao

    You can also search for this author inPubMed Google Scholar

  3. Noriko Hirata

    You can also search for this author inPubMed Google Scholar

  4. Kensuke Namba

    You can also search for this author inPubMed Google Scholar

  5. Takao Nomi

    You can also search for this author inPubMed Google Scholar

  6. Yoshihisa Kitamura

    You can also search for this author inPubMed Google Scholar

  7. Kenzo Moriyama

    You can also search for this author inPubMed Google Scholar

  8. Takahiro Shintani

    You can also search for this author inPubMed Google Scholar

  9. Munekazu Iinuma

    You can also search for this author inPubMed Google Scholar

  10. Hideaki Matsuda

    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toHideaki Matsuda.

Rights and permissions

About this article

Cite this article

Murata, K., Nakao, K., Hirata, N.et al. Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel,Piper betle .J Nat Med63, 355–359 (2009). https://doi.org/10.1007/s11418-009-0331-y

Download citation

Keywords

Access this article

Subscribe and save

Springer+ Basic
¥17,985 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Japan)

Instant access to the full article PDF.

Advertisement

[8]ページ先頭
©2009-2025 Movatter.jp