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Abstract
Ketogenic diet (KD) is an established treatment for refractory pediatric epilepsy and a promising therapy for diverse neurological diseases. Clinical data on KD in migraine—obtained from 150 patients investigated in case reports and prospective studies—suggest that KD may be a rapid onset effective prophylaxis for episodic and chronic migraine. KD would contribute to restore brain excitability and metabolism and to counteract neuroinflammation in migraine, although its precise mechanism is still unclear. Randomized controlled studies are needed to confirm the usefulness of KD in migraine and to investigate its optimal duration, repeatability, feasibility in normal weight subjects, efficacy in pediatric population and association to conventional migraine prophylaxis.
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Effectiveness of ketogenic diet in treatment of patients with refractory chronic migraine
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Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, via Della Pisana 235, Rome, 00163, Italy
Piero Barbanti, Luisa Fofi, Cinzia Aurilia & Gabriella Egeo
Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy
Massimiliano Caprio
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy
Massimiliano Caprio
- Piero Barbanti
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- Luisa Fofi
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- Cinzia Aurilia
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- Gabriella Egeo
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- Massimiliano Caprio
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Correspondence toPiero Barbanti.
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Barbanti, P., Fofi, L., Aurilia, C.et al. Ketogenic diet in migraine: rationale, findings and perspectives.Neurol Sci38 (Suppl 1), 111–115 (2017). https://doi.org/10.1007/s10072-017-2889-6
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