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Journal of Human Genetics
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Glucose-6-phosphate dehydrogenase mutations in Mon and Burmese of southern Myanmar

Journal of Human Geneticsvolume 53, pages48–54 (2008)Cite this article

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is highly prevalent in Southeast Asians.G6PD mutations are associated with specific ethnic groups in Southeast Asia. Mon is a minority ethnic group in Myanmar, which speaks Monic, a distinct language of Mon-Khmer classification. We studiedG6PD mutations in Mon and Burmese males of southern Myanmar who migrated to Thailand in Samutsakhon province. G6PD deficiency was identified in 19 (12%) of 162 Mon males and 17 (10%) of 178 Burmese males, and then assayed forG6PD mutations. Among 19 G6PD-deficient Mons, 12 were G6PD Mahidol; one case each was G6PD Jammu (871G > A; nt 1311C), G6PD Kaiping (1388G > A), G6PD Mediterranean (563C > T), a novel mutation 94(C > G); and three remain unidentified. Among 17 G6PD-deficient Burmese, 12 were G6PD Mahidol; one each was G6PD Coimbra (592C > T), G6PD Kerala-Kalyan (949G > A), and G6PD Valladolid (406C > T); and two remain unidentified. G6PD Mahidol (487G > A) is the most common mutation among Mons and Burmese. All G6PD deficient Mon and Burmese, except for a person with G6PD Valladolid, shared the same haplotype nt93T, nt1311C. Despite a similar language root with Cambodian’s Khmer language, our study suggests that Mon people share a common ancestry with Burmese rather than Cambodians.

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Acknowledgments

We thank Dr. Molee Wanichsuwan for his assistance in collecting blood samples at Samutsakhon Hospital. This research was supported by The Royal Golden Jubilee Ph.D. program of the Thailand Research Fund. We thank Allen Noble, PA, for editorial review of the manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Rama IV Rd, Bangkok, 10330, Thailand

    Issarang Nuchprayoon

  2. Chula Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Issarang Nuchprayoon & Chalisa Louicharoen

  3. Department of Clinical Pathology, Samutsakhon Hospital, Samutsakhon, Thailand

    Warisa Charoenvej

Authors
  1. Issarang Nuchprayoon
  2. Chalisa Louicharoen
  3. Warisa Charoenvej

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Correspondence toIssarang Nuchprayoon.

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Nuchprayoon, I., Louicharoen, C. & Charoenvej, W. Glucose-6-phosphate dehydrogenase mutations in Mon and Burmese of southern Myanmar.J Hum Genet53, 48–54 (2008). https://doi.org/10.1007/s10038-007-0217-3

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