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Historical aspects of Pott’s disease (spinal tuberculosis) management

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Abstract

Introduction

Spinal tuberculosis has existed in human beings since the ascent of man on earth. Historically, the management has progressed from regional orthodox therapies to the current, more effective, drugs.

Materials and methods

Historical perspectives regarding the management have been collated by going through the important publications during the past 6 decades. For convenience, the manuscript has been organized as “orthodox traditional” treatment, early “chemotherapy period”, “post chemotherapy treatment”, “middle-path” philosophy, and the current treatment with availability of modern imaging facilities.

Conclusions

Broad conclusions based upon the published data and personal observations (1959–2011) are summarized as follows: If diagnosis is made at predestructive stage and the patient is treated by standard drugs, the infection would heal in about 95 % patients without significant deformities and complications. Neural complications are still encountered in general hospital outpatients. Diagnosis and treatment at early stages would resolve the neurology without operation in about 40 % of cases. Nearly 60 % of patients would require to be operatively decompressed without jeopardizing mechanical stability. However, despite current treatment approximately 8 % of tuberculous paraplegics do not recover functionally. Immunocompromised state and multidrug resistance to standard drugs (8 to 10 %) are the current (and future) challenges to the doctors and the society.

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References

  1. Lichtor J, Lichtor A (1957) Paleopathological evidence suggesting pre-Columbian tuberculosis of spine. J Bone Joint Surg Am 39-A(6):1938–1939

    Google Scholar 

  2. Duraiswami PK, Orth M, Tuli SM (1971) 5000 years of orthopaedics in India. Clin Orthop Relat Res 75:269–280

    Article PubMed CAS  Google Scholar 

  3. Bick KM (1976) Classics of orthopaedics. JB Lippincott Co., Philadelphia

    Google Scholar 

  4. Tuli SM (2010) Tuberculosis of the skeletal system, 4th edn. Jaypee Brothers Medical Publishers, New Delhi

    Book  Google Scholar 

  5. Barnes PF, Barrows SA (1993) Tuberculosis in the 1990s. Ann Intern Med 119:400–410

    Article PubMed CAS  Google Scholar 

  6. Patel S, Collins DA, Bourke BE (1995) Don’t forget tuberculosis. Ann Rheum Dis 54(3):174–175

    Article PubMed CAS  Google Scholar 

  7. Scott JE, Taor WS (1982) The changing pattern of bone and joint tuberculosis. J Bone Joint Surg Br 64:250

    Google Scholar 

  8. Cameron JA, Robinson CL, Robertson DE (1962) The radical treatment of Pott’s disease and Pott’s paraplegia by extirpation of the diseased area and anterior spinal fusion. Am Rev Respir Dis 86:76–80

    PubMed CAS  Google Scholar 

  9. Chahal AS, Jyoti SP (1980) The radical treatment of tuberculosis of the spine. Int Orthop 4(2):93–99

    PubMed CAS  Google Scholar 

  10. Fellander M (1955) Radical operation in tuberculosis of the spine. Acta Orthop Scand Suppl 19:1–117

    PubMed CAS  Google Scholar 

  11. Hodgson AR, Stock FE et al (1960) Anterior spinal fusion. The operative approach and pathological findings in 412 patients with Pott’s disease of the spine. Br J Surg 48:172–178

    Article PubMed CAS  Google Scholar 

  12. Kohli SB (1967) Radical surgical approach to spinal tuberculosis. J Bone Joint Surg Br 49(4):668–673

    PubMed CAS  Google Scholar 

  13. Kondo E, Yamada K (1957) End results of focal debridement in bone and joint tuberculosis and its indications. J Bone Joint Surg Am 39-A(1):27–31

    PubMed CAS  Google Scholar 

  14. Mukopadhaya B, Mishra NK (1957) Tuberculosis of spine. Indian J Surg 19:59–81

    Google Scholar 

  15. Risko T, Novasazel T (1963) Experience with radical operations in tuberculosis of the spine. J Bone Joint Surg Am 45:53–68

    Google Scholar 

  16. Wilkinson MC (1955) The treatment of tuberculosis of the spine by evacuation of the paravertebral abscess and curettage of the vertebral bodies. J Bone Joint Surg Br 37-B(3):382–391

    PubMed CAS  Google Scholar 

  17. Friedman B (1966) Chemotherapy of tuberculosis of the spine. J Bone Joint Surg Am 48:451–474

    PubMed CAS  Google Scholar 

  18. Kaplan CJ (1959) Conservative therapy in skeletal tuberculosis: an appraisal based on experience in South Africa. Tubercle 40:335–368

    Article  Google Scholar 

  19. Konstam PG, Konstam ST (1958) Spinal tuberculosis in Southern Nigeria with special reference to ambulant treatment of thoracolumbar disease. J Bone Joint Surg Br 40-B(1):26–32

    PubMed CAS  Google Scholar 

  20. Martin M (ed) (1988) Tuberculosis of the bones and joints. Springer, Heidelberg

    Google Scholar 

  21. Roaf R (1958) Tuberculosis of the spine. J Bone Joint Surg Br 40-B(1):3–5

    PubMed CAS  Google Scholar 

  22. Tuli SM (1969) Treatment of neurological complications in tuberculosis of the spine. J Bone Joint Surg Am 51(4):680–692

    PubMed CAS  Google Scholar 

  23. Tuli SM (1975) Results of treatment of spinal tuberculosis by middle-path regime. J Bone Joint Surg Br 57(1):13–23

    PubMed CAS  Google Scholar 

  24. Tuli SM, Kumar S (1971) Early results of treatment of spinal tuberculosis by triple drug therapy. Clin Orthop Relat Res 81:56–70

    Article  Google Scholar 

  25. Vyaghreswarudu C, Reddy Y (1964) Evaluation of treatment in tuberculosis of spine. Indian J Surg 26:911–924

    Google Scholar 

  26. Wilkinson MC (1969) Tuberculosis of the spine treated by chemotherapy and operative debridement: a long-term follow-up study. J Bone Joint Surg Am 51(7):1331–1342

    PubMed CAS  Google Scholar 

  27. Jones R, Levett RW (1923) Orthopaedic surgery. Oxford Medical Publications, London

    Google Scholar 

  28. Dobson J (1951) Tuberculosis of spine: an analysis of the results of conservative treatment and of the factors influencing the prognosis. J Bone Surg Br 33-B(4):517–531

    CAS  Google Scholar 

  29. Editorial (1968) Pott’s paraplegia. Br Med J 2:638–639

  30. Griffiths DL (1952) Tuberculosis of bones and joints: modern practice in tuberculosis, vol 2. Butterworth and Co, London, pp 302–333

  31. Seddon HJ (1935) Pott’s paraplegia, prognosis and treatment. Br J Surg 22:769–799

    Article  Google Scholar 

  32. Mercer W (1964) Then and now: the history of skeletal tuberculosis. J R Coll Surg Edinb 9:243–254

    Google Scholar 

  33. Calot T (1930) Sur le meilleur traitement local des tuberculoses des os, articulations et ganglions lymphatiques. Acta Chir Scand 67:206–226

    Google Scholar 

  34. Albee FH (1930) The bone graft operation for tuberculosis of the spine. JAMA 94:1467–1471

    Article  Google Scholar 

  35. Hibbs RA, Risser JC (1928) Treatment of vertebral tuberculosis by the spine fusion operation. J Bone Joint Surg 10:804–814

    Google Scholar 

  36. Deroy MS, Fisher H (1952) The treatment of tuberculous bone disease by surgical drainage combined with streptomycin. J Bone Joint Surg Am 34:299–330

    PubMed  Google Scholar 

  37. Andre T (1956) Studies on the distribution of tritium-labelled dihydrostreptomycin and tetracycline in the body. Acta Radiol Suppl 142:1–89

    PubMed  Google Scholar 

  38. Barclay WR, Ebert RH, Le Roy GV, Manthei RW, Roth LJ (1953) Distribution and excretion of radioactive Isoniazid in tuberculous patients. JAMA 151(16):1384–1388

    CAS  Google Scholar 

  39. Hanngren A (1959) Studies on the distribution and fate of C14 and T-labelledp-amino-salicylic acid (PAS) in the body. Acta Radiol (Suppl 175):1–118

  40. Wu QQ, Kuan Na XK, Tian WC (1987) The concentrations of four antituberculous drugs in cold abscesses in patients with bone and joint tuberculosis. Chin Med J (Engl) 100:819–822

    CAS  Google Scholar 

  41. Tuli SM, Brighton CT, Morton HE, Clark LW (1974) The experimental induction of localised skeletal tuberculous lesions and their accessibility to streptomycin. J Bone Joint Surg Br 56(4):551–559

    Google Scholar 

  42. Tuli SM, Kumar K, Sen PC (1977) Penetration of antitubercular drugs in clinical osteoarticular tubercular lesions. Acta Orthop Scand 48(4):362–368

    Article PubMed CAS  Google Scholar 

  43. Stevenson FH, Manning CW (1962) Tuberculosis of the spine treated conservatively with chemotherapy: series of 72 patients collected 1949–1954 and followed to 1961. Tubercle 43:406–411

    Article PubMed CAS  Google Scholar 

  44. Martin NS (1970) Tuberculosis of the bones and joints. Springer, Heidelberg

    Google Scholar 

  45. Moon MS, Kim I, Woo YK, Park YO (1987) Conservative treatment of tuberculosis of the thoracic and lumbar spine in adults and children. Int Orthop 11(4):315–322

    Article PubMed CAS  Google Scholar 

  46. Moon MS, Moon YW, Moon JL, Kim SS, Sun DH (2002) Conservative treatment of tuberculosis of the lumbar and lumbosacral spine. Clin Orthop Relat Res 398:40–49

    Article PubMed  Google Scholar 

  47. Langenskiöld A, Riska EB (1967) Pott’s paraplegia treated by antero-lateral decompression in the thoracic and lumbar spine. Acta Orthop Scand 38(2):181–192

    PubMed  Google Scholar 

  48. Medical Research Council (1982) A 10-year assessment of controlled trail comparing debridement and anterior spinal fusion in the management of tuberculosis of the spine in patients on standard chemotherapy in Hong Kong. Eighth report of the Medical Research Council Working Party on Tuberculosis of the Spine. J Bone Joint Surg Br 64:393–398

  49. Arct W (1968) Operative treatment of tuberculosis of the spine in old people. Bone Joint Surg Am 50(2):255–267

    CAS  Google Scholar 

  50. Kirkaldy-Willis WH, Glyn Thomas T (1965) Anterior approaches in the diagnosis and treatment of infections of the vertebral bodies. J Bone Joint Surg Am 47:87–110

    PubMed CAS  Google Scholar 

  51. Kemp HB, Jackson JW, Jeremiah JD, Cook J (1973) Anterior fusion of the spine for infective lesions in adults. J Bone Joint Surg Br 55(4):715–734

    PubMed CAS  Google Scholar 

  52. Girdlestone GR (1965) Tuberculosis of bones and joints. In: Somerville EW, Wilkinson MC (eds), 3rd edn. Oxford University Press, London

  53. Rajasekaran S (2002) The problem of deformity in spinal tuberculosis. Clin Orthop Relat Res 398:85–92

    Article PubMed  Google Scholar 

  54. Jain AK, Maheshwari AV, Jena S (2007) Kyphus correction in spinal tuberculosis. Clin Orthop Relat Res 460:117–123

    Article PubMed  Google Scholar 

  55. Yilmaz C, Selek HY, Gürkan I, Erdemli B, Korkusuz Z (1999) Anterior instrumentation for the treatment of spinal tuberculosis. J Bone Joint Surg Am 81(9):1261–1267

    PubMed CAS  Google Scholar 

  56. Oga M, Arizono T, Takasita M, Sugioka Y (1993) Evaluation of the risk of instrumentation or a foreign body in spinal tuberculosis: clinical and biologic study. Spine 18(13):1890–1984

    Article PubMed CAS  Google Scholar 

  57. Bosworth DM (1963) Modern concepts of treatment of tuberculosis of bones and joints. Ann N Y Acad Sci 106:98–105

    Article PubMed CAS  Google Scholar 

  58. Cauchoix J, Mechelany EF, Tersen G, Morel G, Cotrel Y (1961) Surgical treatment of Pott’s disease. Rev Chir Orthop Reparatrice Appar Mot 47:446–469

    PubMed CAS  Google Scholar 

  59. Smith GW, Robinson RA (1958) The treatment of certain cervical spine disorders by anterior removal of the intervertebral disc and interbody fusion. J Bone Joint Surg Am 40-A(3):607–624

    PubMed CAS  Google Scholar 

  60. Paus B (1964) Treatment for tuberculosis of the spine: anti-tuberculosis drugs in conjunction with radical operation and short hospitalization with no enforced recumbency or immobilization. Acta Orthop Scand (Suppl 72):1–139

  61. Grewal KS, Singh M (1956) Tuberculosis of spine. Indian J Surg 18:394–405

    Google Scholar 

  62. Jain AK, Dhammi IK (2007) Tuberculosis of the spine: a review. Clin Orthop Relat Res 460:39–49

    Article PubMed  Google Scholar 

  63. Rajasekaran S, Shanmugasundaram TK, Prabhakar R, Dheenadhayalan J, Shetty AP, Shetty DK (1998) Tuberculous lesions of the lumbosacral region: a 15-year follow-up of patients treated by ambulant chemotherapy. Spine 23(10):1163–1167

    Article PubMed CAS  Google Scholar 

  64. Hobby GL, Johnson PM, Boytar-Papirnyik V (1974) Primary drug resistance: a continuing study of drug resistance in tuberculosis in a veteran population within the United States. X. September 1970 to September 1973. Am Rev Respir Dis 110(1):95–98

    Google Scholar 

  65. Yeager RL (1963) Opening remarks. Ann N Y Acad Sci 106:3–4

    Article  Google Scholar 

  66. Tuli SM (1999) Preliminary observations on the effect of immunomodulation in multidrug resistant cases of osteo-articular tuberculosis. Ind J Orthop 33:83–85

    Google Scholar 

  67. Arora A, Nadkarni B, Dev G, Chattopadhya D, Jain AK, Tuli SM, Kumar S (2006) The use of immunomodulators as an adjunct to antituberculous chemotherapy in non-responsive patients of osteo-articular tuberculosis. J Bone Joint Surg Br 88(2):264–269

    PubMed CAS  Google Scholar 

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  1. VIMHANS Hospital, Institutional Area, Nehru Nagar, New Delhi, 110065, India

    Surendar M. Tuli

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Tuli, S.M. Historical aspects of Pott’s disease (spinal tuberculosis) management.Eur Spine J22 (Suppl 4), 529–538 (2013). https://doi.org/10.1007/s00586-012-2388-7

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